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Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition) ›› 2017, Vol. 11 ›› Issue (03): 213-217. doi: 10.3877/cma.j.issn.1674-1358.2017.03.002

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Relationship of internal ribosomal entry site (IRES) and enterovirus

Xuefei Ni1, Xingwang Li1,()   

  1. 1. Infectious Diseases Research Center, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China
  • Received:2016-01-21 Online:2017-06-15 Published:2021-09-11
  • Contact: Xingwang Li

Abstract:

Human enteroviruses belonging to Picornaviridae family are nonenveloped virus, which contain a single positive-stranded genomic RNA. The viral genome has 5'-untranslated region (5'-UTR), single open reading frame of encoding polyprotein precursor and 3'-untranslated region (3'-UTR). 5'-UTR RNA contains an internal ribosomal entry site (IRES). When virus infect host, the IRES-mediated initiation of translation enhance the translation of viral RNA, while at the same time host cell translation is shut off. Research on the relationship between IRES and enterovirus is vitally important to antiviral treatment.

Key words: Internal ribosomal, Entry site, Enterovirus

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