To investigate the clinical efficacy and safety of peramivir in the treatment of children with influenza virus infection.

Total of 300 children admitted to Beijing Children’s Hospital who diagnosed with influenza A were divided into peramivir treatment group (150 cases) and oseltamivir treatment group (150 cases) by prospective study method, from June 2016 to January 2017. The fever remission time, symptom relief time and adverse reaction of patients in the two groups were compared after treatment.

The median symptom relief time was 27.9 hours of patients in peramivir group and 42.7 hours of patients in oseltamivir group, with significant difference (t =-18.325,P< 0.001). The median fever remission time were 17.8 hours and 22.3 hours of patients in peramivir treatment group and oseltamivir treatment group, with significant difference (t =-9.365,P< 0.001). No complications occurred in patients of the two groups. The adverse reaction rate was 4% of patients in peramivir group and 7.3% of patients in oseltamivir group, with significant difference (χ²= 1.349,P= 0.246). All adverse reactions were self-mitigating without special treatment.

The use of peramivir for treatment of children with influenza A virus infection could quickly and effectively relieve the symptoms and shorten the duration of fever, with good safety and tolerability.

Interferon-induced transmembrane proteins (IFITMs), a class of novel discovered viral restriction factors, are widely expressed in human tissue cells, mainly located in plasma membrane and endolysosomal comparments, which are the main targets of the virus entry. By inhibiting membrane fusion between virus and cell membrane, IFITMs restrict the entry of a broad spectrum of viruses, including Ebola virus, influenza A virus, severe acute respiratory syndromes (SARS) coronavirus, dengue virus, West Nile virus and Zika virus. Although IFITM has been shown to be able to suppress the infection of virus of the eight virus families, and it primarily inhibits the fusion process of the virus entry stage, but the mechanism of IFITM antiviral activity remains unknown. In recent years, the antiviral effect of IFITM and its mechanism has become a hotspot in related fields. Here the recent advance of IFITM’s antiviral spectrum and underlying mechanism of how these proteins exert antiviral function were reviewed.

To investigate the clinical effects of high sensitivity C-reactive protein (hs-CRP) combined with routine blood test in diagnosis of bacterial infectious diseases in children.

Total of 45 children with bacterial infectious diseases in our hospital from August 2014 to February 2015 were collected as the observation group, and 45 cases of healthy children as control group. The children were treated by hs-CRP test, blood test and joint detection of both, the detection index of the two groups and three detection method in the diagnosis of coincidence rate in the observation group were compared, respectivly.

After detection, the levels of hs-CRP, white blood cell count, neutrophil count in the observation group were (13.75±8.52) mg/L, (11.02±4.31) × 10⁹/L and (7.52±2.65) × 10⁹/L respectively, which were significantly higher than those of control group, with significant differences (t = 8.943, P = 0.000; t = 5.672, P = 0.006; t = 3.417, P = 0.011). In addition, the positive rate of hs-CRP combined with routine blood test was significantly higher than that of the separate detection of hs-CRP or routine blood test, with significant differences (χ²= 12.114, P = 0.000; χ²= 3.814, P = 0.025).

The pediatric infectious disease diagnosis by hs-CRP combined with routine blood test, will improved the diagnosis rate effectively, which should be promoted in the clinical application.

To investigate the clinical characteristics of 231 patients with gonorrhea and the effects of ceftriaxone.

Data of 231 patients who were diagnosed as gonorrhoea by clinical and laboratory tests, and treated with ceftriaxone in the Department of Dermatology, Beijing Ditan Hospital, Capital Medical University from May 2013 to December 2019 were analyzed, retrospectively.

Among the 231 patients, 84.8% (196/231) were male and 97% (224/231) were symptomatic. The median age was 30 (26, 35) years old. Total of 43 cases (18.6%) were co-infected with Chlamydia trachomatis and 50 cases (21.6%) were co-infected with Ureaplasma urealyticum, among whom 15 cases (6.5%) were co-infected with both Chlamydia trachomatis and Ureaplasma urealyticum. The rates of co-infection with Chlamydia trachomatis [31.4% (11/35)] or Ureaplasma urealyticum [77.1% (27/35)] were both higher in female patients than male patients [16.3% (32/196) and 11.7% (23/196)], with significant differences (co-infected with Chlamydia trachomatis: χ² = 4.471, P = 0.034; co-infected with Ureaplasma urealyticum: χ² = 74.912, P < 0.001). After treatment of high dosage ceftriaxone (≥ 1 g), all patients were negative for Neisseria gonorrhoeae, but 10 cases (4.3%) were found Neisseria gonorrhoeae reinfected during follow-up.

Patients with gonorrhoea were often co-infected with Chlamydia trachomatis and other sexually transmitted diseases. Treatment failure were not found in this study after treatment of high dosage ceftriaxone (≥ 1 g). However, reinfection can occur after cure in patients with gonorrhea, so patients with gonorrhea should be followed up for several times after treatment to detect treatment failure or reinfection as soon as possible.

To investigate the use of traditional Chinese and western medicine treatment of Helicobacter pylori infection caused by chronic gastritis effect.

Total of 240 patients with chronic gastritis were collected from August 2013 to December 2015, dividing into control group and treatment group according to the random number table method, 120 cases in each group. The patients in the control group were treated with amoxicillin and clarithromycin as western medicine. The patients in the treatment group were treated with amoxicillin combined with clarithromycin. Treatment cycle were both 30 days, the efficacy of the two groups of patients were compared after the end of treatment.

The total effective rate was 97.5% and the effective rate was 10% of patients in treatment group, which was significantly higher than that of the control group (93.33% and 8.33%), with significant differences (χ² = 3.317, P = 0.012; χ² = 2.103, P = 0.035). After treatment, the degree of gastric mucosal atrophy in the treatment group was not significantly different from that in the control group. The negative rate of Helicobacter pylori of patients in the treatment group was higher than that of the control group, with significant difference (χ² = 2.235, P = 0.034).

The combination of traditional Chinese and western medicine in the treatment of Helicobacter pylori infection caused by chronic gastritis effect is significant.

Siglecs are cell surface transmenbrane receptor and are expressed on the immune cells, which regulated the immune balance in inflammation diseases. Sepsis is organ dysfunction induced by infection, the pathogenesis of sepsis contains the immune disorder, inflammatory reaction and coagulation dysregulation. In this article, we reviewed the role of Siglecs in the pathogenesis of sepsis was reviewed. Siglec-1, Siglec-5 and Siglec-14 play bidirectional role by regulating the inflammation and immunity. Siglec-2 modulates the immune balance in inflammation through regulating B cell and T cell response. Siglec-9 modulates macrophagepolarization and restrain the function of neutrophils during infection through the endocytosis of toll-like receptor 4 (TLR4). Siglec-10 inhibits the danger-associated molecular pattern (DAMP) and helps T cells initiate antigen-antibody responses, and reduces the number of B cells, thus reducing inflammation. Modulation of Siglecs function in different stages of sepsis have potential therapeutic significance in the treatment of sepsis.

To establish an integral assessment diagnostic approach of lung fluke disease (LFD), which based on clinical manifestations, laboratory examination and imaging tests, and to improve the diagnostic level of LFD.

The clinical data of 56 patients with clinically diagnosed LFD in Renmin Hospital of Shiyan City (Renmin Hospital, Hubei University of Medicine) from January 2008 to June 2019 were analyzed, retrospectively. The clinical symptoms, signs, epidemiological history of the patients were recorded; levels of white blood cell (WBC), eosinophil (EOS) count, platelet (PLT) count, serosal cavity effusion index, histopathological examination, sputum smear cytology culture were analyzed, respectively. The nuclear magnetic resonance imaging (MRI), multilayered spiral CT (MSCT), color doppler ultrasound findings were also analyzed, and integration of lung-pulmonary, subcutaneous, cerebrospinal, abdominal symptoms and/or signs at the site of pneumonitis colonization into 2 points per site. With LFD personal history (eating raw crab or crab, drinking raw water) was scored 2 points. WBC 10 × 10⁹/L was scored as 0, increasing 0.1 point for each increased 1 × 10⁹/L. EOS 0.30 × 10⁹/L was scored as 0, increasing 0.1 points for each increased 0.03 × 10⁹/L. Score PLT 300 × 10⁹/L was scored as 0, increasing 0.1 point for each increased 10 × 10⁹/L. The EOS of serous cavity effusion increased and tissue EOS invaded were both scored as 2 points. MRI, MSCT, ultrasound and other detection of chest lung, subcutaneous, spinal cord, abdominal cavity lesions of each organ lesion were all scored as 2 points. Tissue discovery of paragonimus body or eggs, sputum or stool discovery of paragonimus eggs directly was scored as 8 points. The paragonimiasis antigen intradermal test (PAIT) and paragonimiasis antibody test (ELISA-PAb) of paragonimiasis antigen were carried out according to diagnostic criteria of infectious diseases. The sensitivity and specificity of the diagnostic LFD of the "integral diagnostic scale" were analyzed by comparing the positive patients with PAIT and ELISA-PAb, respectively.

According to clinical manifestations (clinical symptoms and signs, personal history), laboratory examination, imaging results, establishment of LFD "integral diagnostic scale " were establishmented. when the patient’s integral diagnostic scale was higher than 9.31, excluding EOS caused by eosinophilia and other related diseases through clinical manifestations (history, physical examination), laboratory examination, imaging examination, pathological examination it could suggest possible LFD. The higher of integral diagnostic scale was, the more possibility likely to LFD. The score of LFD patients was 9.31-25.58. The sensitivity of the diagnostic LFD of integral diagnostic scale was 100% and the specificity was 93.33%.

The diagnostic sensitivity and specificity to LFD of integral diagnostic scale were well and suitable to LFD clinical diagnosis.

To investigate the clinical value of pattern reversal visual evoked potential (P-VEP) in early diagnosis and assessment of optic nerve injury caused by neurosyphilis.

Total of 21 neurosyphilis patients with abnormal P100 wave latency and with P-VEP examination in Beijing Ditan Hospital, Capital Medical University from January 2016 to December 2019 were collected and the P-VEP results, clinical manifestations, characteristics of cerebrospinal fluid and serum indicators were analyzed, respectively.

Among the 21 patients with abnormal P-VEP, most were male (76%, 16/21). The mean age was (45.0 ± 11.5) years old. There were 17 patients with positive ocular symptoms and 4 patients with negative ocular symptoms. All patients with abnormal P-VEP neurosyphilis had optic nerve damage, whether symptomatic or asymptomatic. The abnormality of P-VEP was mainly manifested as prolonged latency of P100 wave. Of the abnormal eyes of P100 latency [(135.16 ± 22.21) ms] was significantly longer than that of normal eyes [(92.75 ± 8.26) ms], with significant difference (t =-2.813, P = 0.007). Patients with positive ocular symptoms had a longer latency of P100 wave [(137.94 ± 23.12) ms] than patients without ocular symptoms [(120.33 ± 5.50) ms], with significant difference (t = 1.28, P = 0.217). There was no correlation between P100 wave latency and white blood cells (r = 0.349, P = 0.155) and protein (r = 0.240, P = 0.323) of cerebrospinal fluid. The clinical data of 8 reexamined patients were analyzed and the changes of P100 wave latency were not consistent with the biochemical manifestations of serum and cerebrospinal fluid (all P > 0.05). Five of the eyes presented P100 wave absence, which did not improve during 6 months after treatment. P100 wave deletion may indicate that the optic nerve damage was irreversible.

Prolonged latency of P100 wave or absence of waveforms in patients with neurosyphilis may indicate optic nerve damage. The absence of a P100 wave form may indicate severe and irreversible optic nerve damage. Abnormal P-VEP may indicate neurosyphilis optic nerve damage earlier than clinical symptoms. It provides a basis for determining the optic nerve damage and the degree of damage in patients with neurosyphilis.

To evaluate the efficacy, safety and influencing factors of two bismuth-containing quadruple therapies in the treatment of recurrent Helicobacter pylori (H. pylor) infection.

Total of 95 patients with H. pylor recurrence infection from March 2017 to October 2020 in Tsinghua University Yuquan Hospital (Tsinghua University Hospital of Integrated Traditional Chinese and Western Medicine) were divided into experimental group (45 cases) and control group (50 cases) by ramdom envelope method, and there were 31 cases and 28 cases with atrophic gastritis in experimental group and control group, respectively. The experimental group were treated with colloidal bismuth pectin (200 mg, twice a day) + rabeprazole (10 mg, twice a day) + amoxicillin (1 000 mg, twice a day) + moxifloxacin (0.4 mg, once a day). The control group were treated with bismuth pectin (200 mg, twice a day) + rabeprazole (10 mg, twice a day) + amoxicillin (1 000 mg, twice a day) + metronidazole (0.4 mg, three times a day). All patients of the two groups were treated for 2 weeks. Then ¹³C urease breath test were performed on cases in both groups after 4-8 weeks. The eradication rate of recurrent H. pylor, eradication rate of cases with atrophic gastritis and the incidence of adverse drug reactions in 4 weeks after treatment were evaluated by Chi-square test. The risk factors for recurrent treatment failure of H. pylor were analyzed by Univariate and multivariate Logistic regression analysis.

In experimental group, 45 cases completed the treatment after relapse, among them, 37 cases with H. pylor infection successfully eradicated, the eradication rates of intention-to-treat analysis (ITT) and per-protocol (PP) were 82.22% (37/45) and 94.87% (37/39), respectively. In control group, 50 cases completed the treatment after relapse, among them, 42 cases with H. pylor infection successfully eradicated, the eradication rates of ITT and PP were 82.22% (42/50) and 87.5% (42/48), respectively. There were no significant differences between the two groups for the eradication rates of ITT (χ² = 0.783, P = 0.800) and PP (χ² = 1.551, P = 0.297). The incidences of adverse reactions of experimental group and control group were 8.0% (4/45) and 12% (6/50), respectively, with no significant difference (χ² = 0.243, P = 0.744). The eradication rates of ITT (96.77% vs. 75.85%) and PP (96.77% vs. 78.57%) after retreatment of patients complicated with atrophic gastritis in experimental group were significantly different from those of the control group (χ² = 5.670, P = 0.017; χ² = 4.662, P = 0.031). Univariate analysis showed that the eradication rates of ITT (91.57% vs. 25.00%) and PP (93.83% vs. 27.27%) between patients with different drug dependence (rate of taking medication ≥ 90% and < 90%) were significantly different (χ² = 28.59, P < 0.001; χ² = 8.138, P = 0.004). However, there was no significant difference for the eradication rates of ITT and PP between patients with different factors, such as age, sex, smoking, alcohol consumption, dyspepsia, dyspepsia, diabetes, hypertension, DOB value and radical drugs (all P > 0.05). Multivariate Logistic analysis showed that drug dependence was a factor influencing the recurrent curative efficacy after the eradication of H. pylori infection (OR = 0.035, 95%CI: 0.007-0.199, P < 0.001).

Both moxifloxacin based bismuth-containing quadruple therapy and metronidazole based bismuth-containing quadruple therapy could be used to treat patients with recurrent H. pylor infection; with similar incidence of adverse reactions. Drug compliance was an independent influencing factor for the efficacy of radical treatment for recurrence of H. pylor infection.

To investigate the value of serum soluble myeloid cell triggered receptor-1 (sTREM-1) in the early diagnosis of severe pneumonia.

Total of 60 patients with pneumonia who were treated in The Second Hospital of Jilin University from June 2021 to December 2021 were incorporated in study group, including 40 severe cases (severe pneumonia group) and 20 mild cases (common pneumonia group). Another 15 physical examiner during the same period were selected as control group. All patients in study group were evaluated by the pneumonia severity index (PSI) score within 24 hours after admission. The immunoscattering turbidimetry, electrochemical luminescence and enzyme-linked immunosorbent assay (ELISA) were used to detect the levels of serum procalcitonin (PCT), hypersensitive C-reactive protein (hs-CRP) and sTREM-1, respectively. The levels of serum sTREM-1 in severe pneumonia group, common pneumonia group and control group within admission 24 hours were compared, and the levels of PCT, hs-CRP and PSI score in severe and common pneumonia group within admission 24 hours were compared, respectively. The correlation between serum sTREM-1 and hs-CRP and PSI score were analyzed by Pearson correlation analysis; the correlation between serum PCT and PSI score were analyzed by Spearson correlation analysis. The value of serum sTREM-1, PCT and hs-CRP in the early diagnosis of severe pneumonia were compared by the area under receiver operating characteristic curve (ROC) by MedCalc software.

The levels of serum sTREM-1 in severe pneumonia group, common pneumonia group and healthy control group (4 864.81 ± 1 314.53 pg/ml, 1 144.58 ± 571.01 pg/ml, 509.11 ± 43.70 pg/ml) were significantly different (F = 109.292, P < 0.001), and the levels of serum sTREM-1 of severe pneumonia group was significantly higher than those of common pneumonia group and control group (t = 10.981, P < 0.001; t = 9.264, P < 0.001). The levels of serum PCT, hs-CRP and PSI score in severe pneumonia group were significantly higher than those in common pneumonia group (Z =-3.360, P = 0.001; t = 2.047, P = 0.048; t = 4.878, P < 0.001). The AUCs of serum sTREM-1, PCT and hs-CRP for diagnosis of severe pneumonia were 1.00, 0.86 and 0.68, respectively (95%CI: 1.0-1.00, 0.73-0.98, 0.51-0.86). When 2 916.92 pg/ml, 0.31 ng/ml and 32.14 mg/L were selected as the Cut-off values, respectively, Youden index was highest; the corresponding sensitivity were 100%, 85% and 85%, while the specificity were 100%, 81% and 50%, respectively. The AUC of sTREM-1 for diagnosis of severe pneumonia was significantly different from those of hs-CRP and PCT (Z = 3.463, P < 0.001; Z = 2.220, P = 0.026). And there was no significant difference between hs-CRP and PCT (Z = 1.454, P = 0.146). The PSI score was positively correlated with the serum sTREM-1 (r = 0.641, P < 0.001) and PCT (r = 0.540, P = 0.001). However, there was no correlation between PSI score and serum hs-CRP (r = 0.269, P = 0.124).

The level of serum sTREM-1 increased in pneumonia, especially in severe cases, which is positively correlated with PSI score. The detection of serum sTREM-1 is valuable for the early diagnosis of severe pneumonia, and its specificity and sensitivity are higher than those of PCT and hs-CRP. It is expected to become a new biomarker for early diagnosis of severe pneumonia.

To investigate the effect of maternal syphilis infection and perinatal outcome after standardized mother-to-child block treatment.

Total of 485 pregnant women and their newborns diagnosed as complicated syphilis during pregnancy were recruited from the Department of Obstetrics and Gynaecology, Beijing Ditan Hospital, Capital Medical University from January 1st, 2015 and June 30th, 2020. The 485 pregnant women were classified to TRUST ≥ 1︰16 group (100 cases with high titre) and TRUST ≤ 1︰8 group (385 cases with low titre) according to TRUST titre of syphilis before delivery. While the 485 pregnant women were divided to standardized treatment group (405 cases) and unstandardized treatment group (80 cases) according to whether received standard treatment of syphilis or not. TRUST titers in pregnant women and newborns, and adverse outcomes (preterm delivery, low birthweight infants, intrauterine or neonatal death, birth defects, neonatal infection, intrauterine distress, neonatal asphyxia, congenital syphilis) of mother and infants were analyzed by Pearson chi-square test, continuous-corrected chi-square test or Fisher’s exact probability method.

For the cases in TRUST ≥ 1︰16 group, the incidence of congenital syphilis in newborns were 12.0% (12/100) and 0% (0/385) (χ² = 47.372, P < 0.001), the incidence of birth defects were 17% (17/100) and 1.7% (6/385) (χ² = 41.9, P < 0.001), the incidence of preterm birth were 13.0% (13/100) and 5.1% (20/385) (χ² = 7.626, P = 0.009), the incidence of neonatal infection were 39.0% (39/100) and 2.7% (10/385) (χ² = 115.82, P < 0.001), the incidence of low birth weight infants was 6.0% (6/100) and 1.3% (5/385) (χ² = 7.915, P = 0.013) compared to those of TRUST ≥ 1︰8 group, all with significant differences. The cases in standardized treatment group compared to those of unstandardized treatment group, the decrease of pregnant TRUST titers compared to pretreatment were 68.0% (276/405) and 33.3% (27/80) (χ² = 33.717, P < 0.001), the negative rate of TRUST titer at birth were 57.8% (235/405) and 28.6% (23/80) (χ² = 22.995, P < 0.001), the incidence of preterm birth were 5.10% (21/405) and 14.3% (12/80) (χ² = 10.148, P = 0.003), the incidence of low-weight infants were 1.48% (6/405) and 6.25% (5/80) (χ² = 6.853, P = 0.022), the incidence of birth defects were 1.7% (7/405) and 20.0% (16/80) (χ² = 45.409, P < 0.001), the incidence of neonatal infection were 1.4% (6/405) and 53.7% (43/80) (χ² = 200.948, P < 0.001), the innate syphilis infection rate were 0% (0/405) and 15% (12/80) (χ² = 56.23, P < 0.001), all with significant differences.

The higher the maternal serum TRUST titer before birth, the higher incidences of neonatal birth defects, congenital syphilis, neonatal infection, premature birth, and low birthweight children; standard drug treatment during pregnancy could effectively treat syphilis during pregnancy, patients could obtain good pregnancy outcomes and neonatal outcomes.

To investigate the effect of ear pressure beans combined with Yiqihuoxueshengji Decoction in infection prevention after gynecological pelvic surgery.

Total of 296 cases with pelvic surgery in our hospital from January 2014 to June 2015 were selected and divided into two groups by the digital table random method. Among whom, 148 cases who were collected as the observation group were given ear pressure beans combined with the Yiqihuoxueshengji Decoction for preventing infection, when the antibiotics were applied in the operation and for infection prevention. The control group with 148 patients were given routine intraoperative and postoperative prophylactic use of antibiotics, all the cases were given postoperative dynamic monitoring for white cell count, C-reactive protein levels and changes of body temperature. Postoperative pain, exhaust, defecation time and the incidence of infection were compared between the two groups after operation.

The concentration of CRP of 3 days and 5 days after operation in both groups were statistically significant (χ² = 8.254, 6.337; P = 0.007, 0.015). But there was no significant difference of postoperative exhaust time between the two groups (t = 0.462, P = 0.543). Compared with the control group, the defecation time was significantly shorter, while the average VAS pain score was significantly lower in patients of the observation group (t = 5.049, 3.161; P = 0.028, 0.041). The incidence of postoperative infection and fever in the study group were 2.03% and 5.41%, respectively, which were 10.81% and 18.24% in control group, with significant differences (χ²= 3.729, 5.661; P = 0.036, 0.024).

The ear pressure beans combined with the Yiqihuoxueshengji Decoction after gynecologic surgery could prevent infection and also relieve pain, shorten the function recovery period.

To investigate the clinical value of lactate dehydrogenase in diagnosis of opportunistic infections in patients with HIV infection.

Total of 708 patients with HIV infection admitted for the first time during January 2010 to December 2015 in Shenzhen the Third People’s Hospital were analyzed, retrospectively. The clinical characteristics and levels of serum lactate dehydrogenase (LDH) were collected after admission. According to the reference value of serum LDH (LDH > 250 U/L and≤250 U/L), the patients were divided into two groups: elevated LDH group (245 cases) and normal LDH group (463 cases).

Among the 708 patients with AIDS who were admitted to hospital for the first time, there were 132 female cases and 576 male cases. In LDH elevated group, there were 182 cases with opportunistic infection (Waldχ²= 29.675,P< 0.001), and 162 cases with pulmonary infection (Waldχ²= 69.328,P< 0.001). The results of Logitic regression single factor analysis showed that lower CD4⁺ T counts (Waldχ²= 60.646,P< 0.001), higher HIV loads (Waldχ²= 25.305,P< 0.001), fungal infections (Waldχ²= 67.264,P< 0.001) and pneumocystis pneumonia (Waldχ² = 101.892,P< 0.001) were more likely to lead to elevated LDH in patients with AIDS, with significant differences. In patients withMycobacteriuminfection, the level of serum lactate dehydrogenase was not easy to increase, without significant difference (Waldχ²= 0.137,P= 0.711). The results of Logitic regression multi-factor analysis showed that HIV RNA viral load>10⁷copies/ml (Waldχ² = 5.175,P= 0.023), pulmonary infection (Waldχ² = 5.096,P= 0.024), blood stream infections (Waldχ²= 9.443,P= 0.002), pneumocystis pneumonia (Waldχ²= 57.216,P < 0.001), fungal infections (Waldχ²= 6.064,P= 0.014) were associated with LDH elevation, with significant differences.

The increase of LDH in patients with AIDS indicated that the infection site tends to be pulmonary infection and blood flow infection, and the infection pathogen tends to PCP and fungal infection, which had certain early clinical diagnostic value.

To investigate the effect of anti-tuberculosis drugs on liver function of patients with acquired immune deficiency syndrome (AIDS) complicated with tuberculosis (TB).

Total of 60 patients with AIDS/TB hospitalized from April 2013 to August 2015 in our hospital were collected as the observation group, while 60 cases with TB were selected as the control group. Patients of both groups were treated with anti-tuberculosis drugs, and the indexes changes of liver function, liver function injury and adverse reactions after treatment were compared, respectively.

The TBil and ALT levels of patients of both groups were with no significant differences before treatment (t = 0.952, P = 0.343; t = 0.608, P = 0.544). After treatment, the levels of TBil and ALT in patients of observation group were significantly higher than those of patients in control group (t = 10.110, P < 0.001; t = 26.098, P < 0.001). The proportion of liver damage of patients in observation group was 46.7%, which was significantly higher than that (21.7%) of the control group (χ² = 8.336, P = 0.004). The period of liver function impairment of the observation group was significantly shorter than that of the control group, while the recovery period of liver function damage was significantly longer than that of the control group (t = 11.970, P < 0.001; t = 9.693, P < 0.001). The incidence of adverse reaction of patients in observation group was 20.0%, which was significantly higher than that (8.3%) of the control group (χ² = 5.634, P < 0.001). The proportion of CD4⁺ T cells of patients with liver injury was (32.82 ± 4.67)%, and that of patients without liver damage was (39.66 ± 4.85)%, with significant difference (t = 7.419, P < 0.001).

During the course of anti-tuberculosis treatment, patients with AIDS/TB had a greater influence on liver function and were more likely to suffer from liver function damage.

To investigate the clinical efficacy of 10% povidone-iodine cream in the treatment of infected skin wounds.

Total of 50 cases with skin infection in Liyuan Hospital Affiliated to Tongji Medical College were collected and divided into the observation group and the control group randomly (25 cases in each group). Patients in the observation group were treated by 10% povidone iodine cream, while the control group were treated with conventional dressings. The treatment efficacy of patients in both groups were compared.

The effective rates were 96% and 80% in the observation group and the control group, respectively, with significant difference (t = 15.62, P = 0.02). The mean wound healing times in the observation group and the control group were (5.3±0.4) days and (10.3±1.3) days, with significant difference (χ² = 8.654, P = 0.03).

The 10% povidone-iodine cream could effectively treat the skin wound and improve the prognosis of patients, and shorten the wound healing time.