Complexity between the Janus kinase-signal transducer and activator of transcription proteins signaling pathway and sepsis

doi:10.3877/cma.j.issn.1674-1358.2022.06.002

Abstract

Abstract:

Sepsis occurs when the body’s response to infection results in end-organ dysfunction, which can cause extensive organ damage and life-threatening medical emergency. Systemic inflammatory response syndrome (SIRS) and compensatory anti-inflammatory response syndrome (CARS) are two main pathways which lead to sepsis-induced organ dysfunction. With further research on the pathogenesis of sepsis, the role of the Janus kinase-signal transducer and activator of transcription proteins (JAK-STAT) signaling pathway in sepsis has gradually attracted more attention. This paper provides an overview of the complexity between the JAK-STAT signaling pathway and sepsis by expounding the role of JAK-STAT signaling pathway in the occurrence, development, regulation and potential new treatment of sepsis.

Key words: Sepsis, Janus kinase-signal transducer and activator of transcription proteins signaling pathway, Cytokines

Xinrui Yu, Hui Zeng. Complexity between the Janus kinase-signal transducer and activator of transcription proteins signaling pathway and sepsis[J]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2022, 16(06): 366-369.

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References 30

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因子		JAK	STAT	作用
Ⅰ类细胞因子
	IL-2	JAK1、JAK3	STAT3、STAT5	诱导T细胞分化
	IL-4	JAK1、JAK3	STAT6	抗炎，诱导Th2细胞分化
	IL-5	JAK2	STAT3、STAT5、STAT6	诱导B细胞成熟
	IL-6	JAK1、JAK2、TYK2	STAT1、STAT3	促炎，诱导免疫细胞成熟活化
	IL-7	JAK1、JAK3	STAT3、STAT5	促进T、B细胞存活
	IL-12	JAK2、TYK2	STAT4	促炎，激活T细胞、NK细胞
	IL-13	JAK1、JAK2、JAK3、TYK2	STAT6	抗炎
	IL-23	JAK2、TYK2	STAT3、STAT4	促炎
	GM-CSF	JAK2	STAT3、STAT5	诱导粒细胞、单核细胞生成
Ⅱ类细胞因子
	IFN-α	JAK1、TYK2	STAT1、STAT2、STAT4	促炎或抗炎
	IFN-β	JAK1、TYK2	STAT1、STAT2、STAT4	抗病毒，促炎
	IFN-γ	JAK1、JAK2	STAT1	促炎，激活单核巨噬细胞，正反馈
	IL-10	JAK1、JAK2、TYK2	STAT1、STAT3	抗炎，诱导Th2分化，上调SOCS
其他
	TNF-α	JAK2	STAT1、STAT3	促炎，正反馈；抗炎
	HMGB1	JAK1、JAK2	STAT1、STAT3	晚期促炎因子，正反馈

因子		JAK	STAT	作用
Ⅰ类细胞因子
	IL-2	JAK1、JAK3	STAT3、STAT5	诱导T细胞分化
	IL-4	JAK1、JAK3	STAT6	抗炎，诱导Th2细胞分化
	IL-5	JAK2	STAT3、STAT5、STAT6	诱导B细胞成熟
	IL-6	JAK1、JAK2、TYK2	STAT1、STAT3	促炎，诱导免疫细胞成熟活化
	IL-7	JAK1、JAK3	STAT3、STAT5	促进T、B细胞存活
	IL-12	JAK2、TYK2	STAT4	促炎，激活T细胞、NK细胞
	IL-13	JAK1、JAK2、JAK3、TYK2	STAT6	抗炎
	IL-23	JAK2、TYK2	STAT3、STAT4	促炎
	GM-CSF	JAK2	STAT3、STAT5	诱导粒细胞、单核细胞生成
Ⅱ类细胞因子
	IFN-α	JAK1、TYK2	STAT1、STAT2、STAT4	促炎或抗炎
	IFN-β	JAK1、TYK2	STAT1、STAT2、STAT4	抗病毒，促炎
	IFN-γ	JAK1、JAK2	STAT1	促炎，激活单核巨噬细胞，正反馈
	IL-10	JAK1、JAK2、TYK2	STAT1、STAT3	抗炎，诱导Th2分化，上调SOCS
其他
	TNF-α	JAK2	STAT1、STAT3	促炎，正反馈；抗炎
	HMGB1	JAK1、JAK2	STAT1、STAT3	晚期促炎因子，正反馈

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