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中华实验和临床感染病杂志(电子版) ›› 2018, Vol. 12 ›› Issue (01) : 7 -10. doi: 10.3877/cma.j.issn.1674-1358.2018.01.002

所属专题: 文献

综述

慢性乙型肝炎患者病毒准种的研究进展
任玉莲1, 宋修光2,()   
  1. 1. 250011 济南市,山东中医药大学附属医院人才中心
    2. 250021 济南市,济南市传染病医院六科
  • 收稿日期:2016-12-20 出版日期:2018-02-15
  • 通信作者: 宋修光

Research progress on hepatitis B virus quasispeices of chronic hepatitis B

Yulian Ren1, Xiuguang Song2,()   

  1. 1. Talent Center, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250011, China
    2. The 6th Department, Jinan Infectious Diseases Hospital, Jinan 250021, China
  • Received:2016-12-20 Published:2018-02-15
  • Corresponding author: Xiuguang Song
  • About author:
    Corresponding author: Song Xiuguang, Email:
引用本文:

任玉莲, 宋修光. 慢性乙型肝炎患者病毒准种的研究进展[J]. 中华实验和临床感染病杂志(电子版), 2018, 12(01): 7-10.

Yulian Ren, Xiuguang Song. Research progress on hepatitis B virus quasispeices of chronic hepatitis B[J]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2018, 12(01): 7-10.

由于乙型肝炎病毒(HBV)的逆转录酶缺乏校正活性,在病毒复制过程中产生大量核苷酸错配,故HBV在宿主体内表现为大量在遗传学上高度相关而又有差别的病毒群体,这一群体称为准种,宿主体内的病毒准种在宿主免疫压力和药物的选择压力下不断发生动态变化,因此HBV准种变化在慢性乙型肝炎的抗病毒治疗、耐药检测以及预后等方面均有重要作用。本文对HBV准种变化与慢性乙型肝炎进展的关系作一综述。

HBV reverse transcriptase lacks proof-reading capacity, which lead to mutation and genetic variation during replication. Consequently, HBV circulates in vivo as a viral population with a spectrum of genetically distinct but closely related variants, known as quasispecies. The quasispecies have dynamic change on immune pressure and antiviral treatment, and play an important roal on the antiviral treatment, drug resistance and outcome of chronic hepatitis B. This paper reviews about the quasispeices change on the progress of chronic hepatits B.

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