Clinical efficacy of the wound healing after photodynamic treatment of Condyloma acuminatum with compound polymyxin B ointment combined with JUC

doi:10.3877/cma.j.issn.1674-1358.2018.02.012

Abstract

Abstract:

Objective

To investigate the effect and safety of compound polymyxin B ointment combined JUC in wound healing after topical aminolaevulinic acid-based photodynamic therapy (5-ALA-PDT) for the condyloma acuminatum.

Methods

Total of 231 patients with condyloma acuminatum from our outpatient-room, were divided into two groups randomly. After 5ALA-PDT therapy, patients in the control group topically used 3% boric acid solution, and patients in the treatment group topically used compound polymyxin B ointment combined with JUC besides 3% boric acid solution.

Results

Compared with the control group (13.82%, 10.57%, 4.07% and 10.6%), the pain incidence rates (5.56%), the infection incidence rates (2.78%), the incidence rates of the scar and pigment residue (0%), the relapse rate (3.7%) of patients in the treatment group were all with significant differences (all P < 0.05).

Conclusions

Compound polymyxin B ointment combined with JUC could be used effectively and safely after 5ALA-PDT treatment for condyloma acuminatum. The combined treatment could release the pain and the rates of recurrence and with less adverse reaction.

Key words: Compound polymyxin B ointment, Jieyoushen (JUC), Condyloma acuminatum, Photodynamic therapy

Xiaoyang Wang, Xiaoling Chu, Liyuan Sun. Clinical efficacy of the wound healing after photodynamic treatment of Condyloma acuminatum with compound polymyxin B ointment combined with JUC[J]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2018, 12(02): 160-164.

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References 22

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临床资料		治疗组（108例）	对照组（123例）	统计量	P值
男/女（例）		61/47	66/57	χ² = 0.185	0.667
平均年龄（ ± s，岁）		31.0 ± 10.3	31.5 ± 8.1	t = －0.358	0.721
皮损部位[例（%）]				χ² = 0.295	0.840
	外阴	79（73.14）	90（73.17）
	肛周	22（20.37）	23（18.70）
	外阴+肛周	7（6.48）	10（8.13）
病程[M（Q1，Q3），周）]		3（2，6）	2（2，4）	t = 1.499	0.820

临床资料		治疗组（108例）	对照组（123例）	统计量	P值
男/女（例）		61/47	66/57	χ² = 0.185	0.667
平均年龄（ ± s，岁）		31.0 ± 10.3	31.5 ± 8.1	t = －0.358	0.721
皮损部位[例（%）]				χ² = 0.295	0.840
	外阴	79（73.14）	90（73.17）
	肛周	22（20.37）	23（18.70）
	外阴+肛周	7（6.48）	10（8.13）
病程[M（Q1，Q3），周）]		3（2，6）	2（2，4）	t = 1.499	0.820

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