Effect of laparoscopic appendectomy on serum inflammatory factors and gastrointestinal function for patients with appendicitis

doi:10.3877/cma.j.issn.1674-1358.2018.02.013

Abstract

Abstract:

Objective

To investigate the effect of laparoscopic appendectomy on serum inflammatory factors and gastrointestinal function for patients with appendicitis.

Methods

Total of 155 patients with appendicitis underwent appendectomy who were selected in our hospital from January 2015 to March 2017 and were divided into the observation group (85 cases) and control group (70 cases) according to whether with laparoscopic surgery. The patients in observation group underwent laparoscopic appendectomy, and patients in the control group received open appendectomy. The levels of serum inflammatory factors and postoperative gastrointestinal function recovery indexes were analyzed before and after surgery in both groups, respectively.

Results

Preoperative serum levels of α-tumor necrosis factor (TNF-α) (t = 0.171, P = 0.865), C-reactive protein (CRP) (t = 0.556, P = 0.579), and amyloid A (SAA) (t = 0.317, P = 0.752) were not significantly different between the two groups. After operation, the serum levels of TNF-α (t = 2.604, P = 0.010), CRP (t = 6.061, P < 0.001) and SAA (t = 2.134, P = 0.034) in the observation group were significantly lower than those of the control group, with significant differences. The operation time of the patients in observation group was significantly longer than that of the control group (t = 6.703, P < 0.001), and the amount of bleeding (t = 14.168, P < 0.001), postoperative recovery time of bowel sounds (t = 3.859, P < 0.001), postoperative anal exhaust time (t = 3.374, P = 0.001), defecation time after operation (t = 2.994, P = 0.003) and postoperative hospitalization time (t = 6.917, P < 0.001) were significantly lower than those of the control group, with significant differences.

Conclusions

Compared with open appendectomy, laparoscopic appendectomy could effectively reduce postoperative inflammatory factors and promote gastrointestinal function recovery.

Key words: Laparoscopic appendectomy, Open appendectomy, Appendicitis, Inflammatory factor, Gastrointestinal function

Youguan Ou, Lei Zhu, Haiyan Wu. Effect of laparoscopic appendectomy on serum inflammatory factors and gastrointestinal function for patients with appendicitis[J]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2018, 12(02): 165-168.

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References 21

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组别	例数	性别（男/女，例）	年龄（ ± s，岁）	分型（急性/慢性，例）
观察组	85	45/40	35.7 ± 16.2	78/7
对照组	70	36/34	35.1 ± 15.0	61/9
统计量		χ² = 0.035	t = 0.912	χ² = 0.886
P值		0.851	0.114	0.347

组别	例数	性别（男/女，例）	年龄（ ± s，岁）	分型（急性/慢性，例）
观察组	85	45/40	35.7 ± 16.2	78/7
对照组	70	36/34	35.1 ± 15.0	61/9
统计量		χ² = 0.035	t = 0.912	χ² = 0.886
P值		0.851	0.114	0.347

组别		例数	TNF-α（ng/ml）	CRP（mg/L）	SAA（mg/L）
手术前
	观察组	85	82.5 ± 22.7	22.4 ± 9.1	85.1 ± 24.7
	对照组	70	81.9 ± 20.6	21.6 ± 8.7	83.9 ± 21.9
t值			0.171	0.556	0.317
P值			0.865	0.579	0.752
手术后
	观察组	85	50.2 ± 17.9	10.5 ± 3.5	42.7 ± 18.1
	对照组	70	58.1 ± 19.5	14.2 ± 4.0	49.4 ± 20.5
t值			2.634	6.140	2.160
P值			0.009	< 0.001	0.032

组别		例数	TNF-α（ng/ml）	CRP（mg/L）	SAA（mg/L）
手术前
	观察组	85	82.5 ± 22.7	22.4 ± 9.1	85.1 ± 24.7
	对照组	70	81.9 ± 20.6	21.6 ± 8.7	83.9 ± 21.9
t值			0.171	0.556	0.317
P值			0.865	0.579	0.752
手术后
	观察组	85	50.2 ± 17.9	10.5 ± 3.5	42.7 ± 18.1
	对照组	70	58.1 ± 19.5	14.2 ± 4.0	49.4 ± 20.5
t值			2.634	6.140	2.160
P值			0.009	< 0.001	0.032

组别	例数	手术时间（min）	术中出血量（ml）	术后肠鸣音恢复时间（h）	术后肛门排气时间（h）	术后肛门排便时间（h）	术后住院时间（d）
观察组	85	57.3 ± 9.8	18.5 ± 5.7	13.2 ± 5.5	20.5 ± 6.7	37.1 ± 8.0	4.4 ± 1.5
对照组	70	47.5 ± 8.4	32.7 ± 6.6	16.8 ± 6.0	24.3 ± 7.2	41.1 ± 8.5	6.4 ± 2.0
t值		6.703	14.168	3.859	3.374	2.994	6.917
P值		< 0.001	< 0.001	< 0.001	0.001	0.003	< 0.001

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