To investigate the efficacy of circumcision combined with photodynamic in the treatment of condyloma acuminatum.

From January 2016 to May 2018, a total of 154 cases with condyloma acuminatum complicated with redundant prepuce or phimosis of outpatient-room Department of Dermatology, Beijing Anzhen Hospital, Capital Medical University were collected, who were divided into two groups by random digital method. The 77 patients in control group were treated with photodynamic therapy, while in treatment group, 77 patients were treated with circumcision on the basis of the control group.

The recurrence rates of patients in the treatment group (1.5% and 1.3%) were significantly lower than those of the control group (13.0% and 13.0%), at the first and second week following up after treatment (χ² = 5.7840, P = 0.0162; χ² = 7.8081, P = 0.0052). The overall effective rate and recurrence rate of patients in the treatment group were 99.0% and 0.98%, respectively, which were 92.9% and 7.14% in control group , respectively, with significant differences (all P < 0.001). The postoperative pain rate of patients in treatment group (9.1%) was lower than that of the control group (6.5%), but with no significant difference (χ² = 0.3615, P = 0.5477). There was no significant difference in VAS score between the two groups (Z =-1.0842, P = 0.2783). One case occurred wound infection in each group. There were one case with adverse reactions in control group and one case in treatment group from 1 week to 6 months after treatment (both had pigmentation at the treatment site), with no significant difference between the two groups (P > 0.9999).

For patients with condyloma acuminatum complicated with redundant prepuce or phimosis, the recurrence rate of condyloma acuminatum was significantly reduced by circumcision after photodynamic therapy.