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中华实验和临床感染病杂志(电子版) ›› 2017, Vol. 11 ›› Issue (03) : 209 -212. doi: 10.3877/cma.j.issn.1674-1358.2017.03.001

综述

亚急性硬化性全脑炎研究进展
侯存军1, 邵志英2, 赵晓3,()   
  1. 1. 264100 烟台市,烟台市传染病医院皮肤性病科
    2. 264100 烟台市,烟台市传染病医院科教科
    3. 264100 烟台市,烟台市传染病医院查体中心
  • 收稿日期:2016-02-02 出版日期:2017-06-15
  • 通信作者: 赵晓
  • 基金资助:
    烟台市科技发展计划项目(No. 2011249)

Advances on researching of subacute sclerosing panencephalitis

Cunjun Hou1, Zhiying Shao2, Xiao Zhao3,()   

  1. 1. Division of Skin Venereal division, Yantai City Hospital for Infectious Disease, Yantai 264100, China
    2. Department of Science and Education, Yantai City Hospital for Infectious Disease, Yantai 264100, China
    3. Physical Examination Center, Yantai City Hospital for Infectious Disease, Yantai 264100, China
  • Received:2016-02-02 Published:2017-06-15
  • Corresponding author: Xiao Zhao
引用本文:

侯存军, 邵志英, 赵晓. 亚急性硬化性全脑炎研究进展[J/OL]. 中华实验和临床感染病杂志(电子版), 2017, 11(03): 209-212.

Cunjun Hou, Zhiying Shao, Xiao Zhao. Advances on researching of subacute sclerosing panencephalitis[J/OL]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2017, 11(03): 209-212.

亚急性硬化性全脑炎为一种严重的少见疾病,多由婴幼儿麻疹患者发展而来,麻疹疫苗接种会大大降低其发病率;发病与自身免疫系统不完善和病毒变异有关。若麻疹病毒(MV)在脑内不能及时清除,则会对中枢神经系统造成不可逆损伤,表现为智力减退、语言障碍和癫痫等,可出现脑电图和影像学异常表现,脑脊液抗-MV升高。治疗以抗病毒、提高免疫力和对症治疗为主,虽然新的治疗方法仍在探索中,但目前尚无满意疗法。

Sclerosing panencephalitis (SSPE) is a kind of rare and severe disease, which was mostly developed from infant patients infected with measles virus (MV). The causes of SSPE were related to autoimmunodeficiency of patients and variation of MV, then leading to the infection of brain which lasts for a long period, and the injury of central nervous system is irreversible. The clinical symptoms include intellective degeneration, language disorder, epilepsy and so on. The patients also occur abnormality of electroencephalogram, imageology and antibody of measles virus. Vaccine inoculation has made the incidence decrease of SSPE significantly. The therapeutic methods are focused on inhibition of MV and elevation the patients’ immunity. Unfortunately, new therapies of this disease are still in exploration.

[1]
Ibrahim SH, Amjad N, Saleem AF, et al. The upsurge of SSPE--a reflection of national measles immunization status in Pakistan[J]. Trop Pedratr,2014,60(6):449-453.
[2]
Bellini WJ, Rota JS, Lowe LE, et al. Subacutesclerosingpanencephalitis: more cases of this fatal disease are prevented by measles immunization than was previously recognized[J]. Infect Dis,2005,192(10):1686-1693.
[3]
Sonia M, Lalit D, Shobha B, et al. Subacute sclerosingpanenc ephalitis in a tertiary care centre in post measles vaccination era[J]. Commun Dis,2009,41(3):161-167.
[4]
Campbell H, Andrews N, Brown KE, et al. Review of the effect of measles vaccination on the epidemiology of SSPE[J]. Int Epidemiol,2007,36(6):1334-1348.
[5]
Anselem O, Tsatsaris V, Lopez E, et al. Measles and pregnancy[J]. Presse Med,2011,40(11):1001-1007.
[6]
Kerdiles YM, Sellin CI, Druelle J, et al. Immunosuppression caused by measles virus: role of viral proteins[J]. Rev Med Virol,2006,16(1):49-63.
[7]
Oglesbee M, Niewiesk S. Measles virus neurovirulence and host immunity[J]. Future Virol,2011,6(1):85-99.
[8]
Dajana R, Jürgen SS. Measles virus infection of the CNS: human disease, animal models, and approaches to therapy[J]. Med Microbiol Immunol,2010,199(9):261-271.
[9]
Karakas-Celik S, Piskin IE, KeniMF, et al. May TLR4Asp299Gly and IL-17 His161Arg polymorphism be associated with progression ofprimary measles infection to subacute sclerosing panencephalitis?[J]. Gene,2014,547(2):186-190.
[10]
Jiang DP, Ide YH, Nagano-Fujii M, et al. Single-point mutations of the M protein of a measles virus variant obtained from a patient with subacute sclerosing panencephalitis critically affect solubility and subcellularlocalization of the M protein and cell-free virus production[J]. Microbes Infect,2009,11(4):467-475.
[11]
Abe Y, Hashimoto K, Watanabe M, et al. Characteristics of viruses derived from nude mice with persistentmeasles virus infection[J]. Virol,2013,87(8):4170-4175.
[12]
Hotta H, Nihei K, Abe Y, et al. Full-length sequence analysis of subacute sclerosing panencephalitis (SSPE) virus, a mutant of measles virus, isolated from brain tissues of a patient shortly after onset of SSPE[J]. Microbiol Immunol,2006,50(7):525-534.
[13]
Watanabe S, Shirogane Y, Suzuki SO, et al. Mutant fusion proteins with enhanced fusion activity promote measles virus spread in humanneuronal cells and brains of suckling hamsters[J]. Virol,2013,87(5):2648-2659.
[14]
Watanabe S, Ohno S, Shirogane Y, et al. Measles virusmutants possessing the fusion protein with enhanced fusion activity spreadeffectively in neuronal cells, but not in other cells, without causing strong cytopathology[J]. Virol,2015,89(5):2710-2717.
[15]
Baricevic M, Forcic D, Santak M, et al. A comparison of completeuntranslated regions of measles virus genomes derived from wild-type viruses and SSPE brain tissues[J]. Virus Genes,2007,35(1):17-27.
[16]
Jehmlich U, Ritzer J, Grosche J, et al. Experimental measlesencephalitis in Lewis rats: dissemination of infected neuronal cell subtypes[J]. Neurovirol,2013,19(5):461-470.
[17]
Har-Even R, Aichenbaum S, Rabey JM, et al. Measles-vaccinated Israeli boy with subacutesclerosingpanencephalitis[J]. Pediatr Neurol,2011,44(6):467-470.
[18]
Mahadevan A, Vaidya SR, Wairagkar NS, et al. Case of fulminant-SSPE associated withmeasles genotype D7 from India: an autopsy study[J]. Neuropathology,2008,28(6):621-626.
[19]
Samlıoğlu P, Unalp A, Gökçay A, et al. Subacutesclerosingpanencephalitis cases diagnosed by increased CSF/serum measlesantibody indices[J]. Mikrobiyol Bul,2012,46(4):716-718.
[20]
Simmonds M, Brown DW, Jin L. Measles viral load may reflect SSPE diseasepro-gression[J]. Virology,2006,3(10):1-9.
[21]
Steiner I, Livneh V, Hoffmann C, et al. Steroid-responsive, progressive, focal measles virus brain infection[J]. Ann Neurol, 2014,75(6):967-970.
[22]
Har-Even R, Aichenbaum S, Rabey JM, et al. Measles-vaccinated Israeli boy with subacutesclerosingpanencephalitis[J]. Pediatr Neurol,2011,44(6):467-470.
[23]
Trottier C, Chabot S, Mann KK, et al. Retinoids inhibit measles virus invitro via nucear retinoid receptor signaling pathways[J]. Antiviral Res,2008,80(1):45-53.
[24]
Zinke M, Kendl S, Singethan K, et al. Clearance of measles virus from persistently infectedcells by short hairpin RNA[J]. Virol,2009,83(18): 9423-9431.
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