To investigate the distribution of pathogens and antimicrobial drugs application in complex urinary tract infection.

The clinical data of 1 215 cases with complicated urinary tract infection in our hospital from June 2014 to June 2015 were analyzed, retrospectively, while the application status of antimicrobial drugs were analyzed.

There were 840 Gram-negative bacteria, 260 Gram-positive bacteria and 115 fungi in pathogenic bacteria, accounted for 69.14%, 21.40% and 9.47%, respectively. The percentage of Gram-negative bacteria was significantly higher than that of the other two bacteria groups, with significant differences (χ² = 16.32, P = 0.0000). Total of 840 strains of Gram-negative bacteria were collected, including E. coli, Klebsiella pneumoniae, Proteus mirabilis as main flora, a total of 675 (80.36%) strains. The drug resistance rate of 3 strains to gentamicin, ciprofloxacin and penicillin and 3 generation cephalosporins except for ceftazidime were higher than 50%, which were less than 10% to the imipenem, amikacin, cefperazone-sulbactam. There were 260 strains of Gram-positive bacteria, including Fecal enterococcus, Urine enterococcus as main flora, both for a total of 204 strains, accounting for 78.46%. Vancomycin, teicoplanin, linezolid had no drug resistance to Enterococcus. The high concentration of gentamicin, ciprofloxacin had high resistance to Enterococcus.

The main pathogenic bacteria of complex urinary tract infection are Gram-negative bacteria, while ampicillin/clavulanic acid, cefoperazone and ceftriaxone, amikacin, aztreonam and imipenem and meropenem were all effective.