Effect evaluation on the implementation of two-doses varicella vaccine, prevention and control strategy in a district of Beijing

doi:10.3877/cma.j.issn.1674-1358.2017.04.015

Abstract

Abstract:

Objective

To investigate the Guidelines of Varicella Vaccine in Beijing (Trail), to explore the feasibility of the protective effect of varicella vaccine and to provide further varicella outbreak control measures.

Methods

According the data from the Chinese centre for Disease Control and Prevention (CDC), the reported cases of varicella were studied and analyzed in Haidian Distrct of Beijing from 2010 to 2015.

Results

Total of 13 548 cases of varicella vaccine were reported by the CDC of Haidian District in Beijing from 2010 to 2015, while the annual incidence were gradually decreasing with 90.05/100 000, 83.24/100 000, 72.00/100 000, 66.07/100 000, 53.39/100 000 and 50.72/100 000, respectively. The incidence rates of varicella in patient collected from 2010 to 2012 and from 2013 to 2015 were with significant difference (χ² = 438.312, P < 0.001). There was a significant difference for the cases aged 4-7 years old, 7-20 years old and above 20 years old between patients collected from 2010 to 2012 and from 2013 to 2015 were with the incidences of 81.19/100 000 and 56.62/100 000 (χ² = 273.823, P < 0.001), 832.38/100 000 and 365.89/100 000 (χ² = 273.823, P < 0.001), 258.30/100 000 and 195.37/100 000 (χ² = 25.000, P < 0.001), respectively. The cases aged 1-4 years old were with incidences of 284.49/100 000 and 282/27/100 000 among the patients collected from 2010-2012 and those from 2013-2015, with significant difference (χ² = 0.022, P = 0.883).

Conclusions

The incidence of varicella was gradually declining after the implementation of the Guidelines of Varicella Vaccine in Beijing (Trail) in 2013. The two-doses varicella vaccine could effectively protect the susceptible population.

Key words: Varicella, Epidemic situation, Prevention and control stratgies

Muiping Xu, Chunzhi Chen, Juan Li. Effect evaluation on the implementation of two-doses varicella vaccine, prevention and control strategy in a district of Beijing[J]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2017, 11(04): 388-391.

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References 26

[1]	杨绍基主编. 传染病学[M]. 7版. 北京: 人民卫生出版社. 2008:65-66.
[2]	中华人民共和国卫生部. 国家突发公共卫生事件相关信息报告管理工作规范(试行)[S]. 2005,5.
[3]	北京市疾病预防疾控中心. 北京市水痘疫苗使用技术指南(试行) [S]. 2012,10.
[4]	顾雯雯, 许二萍, 刘仕俊, 等. 2015年杭州市3-10岁儿童水痘减毒活疫苗接种情况分析[J]. 疾病监测,2016,31(2): 151
[5]	许国章. 水痘及其免疫预防研究进展[J]. 中国计划免疫,2002,8(1):52-56.
[6]	Izurieta HS, Strebel PM, Blake PA. Post licensure effective-ness of varicella vaccine during an outbreak in a child care center[J]. JAMA,1997,278(18):1495-1499.
[7]	孙海燕, 袁家麟, 王树巧. 人群中水痘:带状疱疹病毒流行率及其疫苗免疫效果[J]. 中华流行病学杂志,2001,22(1):60.
[8]	Bonhoeffer J, Baer G, Muehleisen B, et al. Prospective surveillance of hospitalisations associated with varicella-zoster virus infections in children and adolescents[J]. Eur J Pediatr,2005,164(6):366-370.
[9]	Somekh E, Dalal I, Shohat T, et al. The burden of uncomplicated cases of chickenpox in Israel[J]. J Infect,2002,45(4):233-236.
[10]	Lungu O, Annunziato PW, Gershon A, et al. Reactivated and latent varicella-zoster virus in human dorsal root ganglia[J]. Proc Natl Acad Sci USA,1995,92(24):10980-10984.
[11]	Katz J, Cooper EM, Walther RR, et al. Acute pain in herpes zoster and its impact on health-related quality of life[J]. Clin Infect Dis,2004,39(3):342-348.
[12]	彭志强, 郑慧贞, 吴承刚, 等. 2005-2009年广东省水痘流行病学分析[J]. 华南预防医学,2011,37(10):9-12.
[13]	吴强松, 刘敏, 李申生, 等. 上海市徐汇区学生水痘疫苗接种及其保护效果分析[J]. 中国学校卫生,2013,34(4):467
[14]	WHO. Varicella vaccine[J]. Wkly Epi Rec,1998,73(32):241-248.
[15]	许青, 徐爱强. 我国水痘流行病学分析与水痘疫苗免疫预防研究进展[J]. 中国新药杂志,2012,21(10):1094
[16]	殷大鹏, 宋立志, 张晓曙, 等. 鲁甘湘三省2007年水痘门诊病例经济负担调查[J]. 中国疫苗和免疫,2009,15(2):123-126.
[17]	刘俊, 肖绍坦, 费怡, 等. 儿童两剂水痘疫苗接种的研究进展[J]. 上海预防医学,2013,25(8):475.
[18]	夏颖苹, 李寿俊, 董维波, 等. 2013年浙江省奉化市水痘疫情流行特征及水痘疫苗保护效果评价[J]. 疾病监测,2014,29(12):959.
[19]	何蔚云, 梁建华, 吴莉, 等. 儿童集体单位水痘暴发与水痘疫苗接种效果的病例对照研究[J]. 热带医学杂志,2012,12(5):617-619.
[20]	杨立清, 李丽, 张楠, 等. 水痘疫苗2剂接种程序对北京市朝阳区水痘发病的影响[J]. 中国生物制品学杂志,2015,28(11):1179.
[21]	庞红, 王晨, 江燕, 等. 学校水痘暴发中水痘疫苗保护率的比较[J]. 中国生物制品学杂志,2015,28(1):70.
[22]	Kim SH, Lee HJ, Park SE, et al. Seroprevalence rate after one dose of varicella vaccine in infants[J]. J Infect,2010,61(1):66-72.
[23]	Tafuri S, Martinelli D, De Palma M, et al. Report of varicella outbreak in a low vaccination coverage group of otherwise healthy children in Italy: the role of breakthrough and the needof a second dose of vaccine[J]. Vaccine,2010,28(6):1594-1597.
[24]	Vázquez M, LaRussa PS, Gershon AA, et al. Effectiveness over time of varicella vaccine[J]. JAMA,2004,291(7) :851-855.
[25]	Chaves SS, Gargiullo P, Zhang JX, et al. Loss of vaccine-induced immunity to varicella over time[J]. N Engl J Med,2007,356(11):1121-1129.
[26]	富继业, 孙培源, 史如晶, 等. 2006-2010年北京市海淀区中小学校及托幼机构水痘暴发疫情流行病学分析[J]. 首都公共卫生,2012,6(2):82.

年龄组	试验组发病率（/10万）	对照组发病率（/10万）	χ²值	P值
0～4岁	282.3	284.5	0.02	0.883
4～7岁	365.9	832.4	273.82	< 0.001
7～20岁	195.4	258.3	98.28	< 0.001
> 20岁	28.7	33.0	25.00	< 0.001
合计	56.6	81.2	438.31	< 0.001

年龄组	试验组发病率（/10万）	对照组发病率（/10万）	χ²值	P值
0～4岁	282.3	284.5	0.02	0.883
4～7岁	365.9	832.4	273.82	< 0.001
7～20岁	195.4	258.3	98.28	< 0.001
> 20岁	28.7	33.0	25.00	< 0.001
合计	56.6	81.2	438.31	< 0.001

年龄	2010至2012年组		2013至2015年组
年龄	发病例数	发病率（1/10万）	发病例数	发病率（1/10万）
0～4岁	673	284.49	730	282.27
4～7岁	1 210	832.38	556	365.89
7～20岁	3 158	258.30	2 067	195.37
> 20岁	2 560	33.00	2 594	28.71
合计	7 601	81.19	5 947	56.62

年龄	2010至2012年组		2013至2015年组
年龄	发病例数	发病率（1/10万）	发病例数	发病率（1/10万）
0～4岁	673	284.49	730	282.27
4～7岁	1 210	832.38	556	365.89
7～20岁	3 158	258.30	2 067	195.37
> 20岁	2 560	33.00	2 594	28.71
合计	7 601	81.19	5 947	56.62

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