To investigate the etiology and prevention of the infection of ankle wound infection and skin flap transplantation.

The pathogenic bacteria selected from 128 cases with wound infection of foot ankle from June 2014 to December 2015 were analyzed, retrospectively. The samples were collected before skin flap transplantation including classification, drug sensitivity and drug resistance of pathogenic bacteria. The treatment included systemic antimicrobial therapy according to the result of drug sensitivity test and an appropriate skin flap. The therapeutic effect was evaluated.

The pathogenic bacteria were detected from 128 cases with wound infection of foot ankle, mainly including Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Enterobacter cloacae, coagulase negative Staphylococcus, Pneumonia Klebsiella and so on. The higher resistance rate of Gram-negative bacilli was extended spectrum β-lactamase (ESBL). Two imipenem resistance strains and one meropenem resistant strains were found. The higher resistance rate of detected Gram-positive coccus was Enterococcus methicillin. The detection rate of methicillin-resistant Staphylococcus aureus (MRSA) was 32.14% (9 strains). The vancomycin and teicoplanin resistant strains were not found. After systemic antimicrobial therapy and appropriate flap surgery, 128 patients all achieved clinical recovery.

The treatment for foot ankle wound with infection should include early judgment of infection and the suitable flap operation. Effective anti-infection, completely clear and grasping the timing of surgery are the key factors of the successful operation.