To investigate the distribution and drug resistance of pathogenic bacteria from blood, and to provide experiment basis for clinical treatment of bloodstream infection.

Positive blood culture from March 2010 to October 2013 were analyzed, retrospectively.

Total of 248 strains were isolated from blood samples, the top 3 groups were E. coli (40.73%), S. epidermidis (19.76%) and K. pneumoniae (9.27%). ESBLs were produced in 44.55% of E. coli and 20.69% of K. pneumonia, respectively. The resistant rates of ESBLs positive strains were higher than those non-ESBLs-produced strains. E. coli strains of drug-resistance to imipenem and meropenem were detected. The isolated rate of MRSA and MRSE accounted for 46.67% and 69.39%, respectively. None of Gram-positive cocci was resisitant to vancomycin and teicoplanin, and linezolid and quinupristin/dalfopristin were also with lower Staphylococcus resistant rate.

Enterobacteriaceae bacteria were the common pathogens in blood infection, and the highest sensitive drug was carbapenems. Blood infection surveillance should be strengthened so as to understand the distribution and drug resistance of pathogenic, and to develop the effective treatment program and improve the cure rate.