Etiological detection of hand, foot and mouth disease in Tianmen in 2014

doi:10.3877/cma.j.issn.1674-1358.2016.03.019

Abstract

Abstract:

Objective

To investigate the infection of Coxsaekie virus A16 (CoxA16) and entervirus 71 (EV71) about hand, foot and mouth disease (HFMD) suspected child in Tianmen, and to provide reference for better treatment and intervention.

Methods

The blood specimens of children suspected with hand, foot and mouth disease were collected, and then CoxA16-IgM and EV71-IgM antibody in serum were detected by ELISA.

Results

Total of 3 009 cases of HFMD suspected children were collected, the total of positive rate was 13.2% (396/3 009), the positive rate of CoxA16-IgM was 10.77% (149/1 384), the positive rate of EV71-IgM was 15.2% (247/1 625), the positive rate of CoxA16-IgM + EV71-IgM co-infection was 10.77% (146/1 381). The boy’s amount was larger than the girl’s in both simple infection and the mixed infection, both with significant differences (χ²_EV71 = 4.60, P = 0.017; χ²_CoxA16 = 4.64, P = 0.025; χ²_{EV71 + CoxA16} = 4.36, P = 0.030). The highest positive rate was patients in one years old group (compared with other groups, P all = 0.000).

Conclusions

The infection rate of HFMD in Tianmen was very high, and the major pathogen was EV71. It was very serious that mixed infection was CoxA16 + EV71, thus, department for disease prevention and control should pay more attention to HFMD and prevent HFMD outbreaking.

Key words: Hand, foot and mouth disease, Coxsaekie virus A16 (CoxA16), Entervirus 71 (EV71), Mixed infection

Mingchao Zhu, Ya Zhu, Lirong Han, Li Sun. Etiological detection of hand, foot and mouth disease in Tianmen in 2014[J]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2016, 10(03): 342-345.

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年龄	例数（男/女）			构成比（%）
年龄	EV71（+）	CoxA16（+）	EV71 + CoxA16（+）	EV71（+）	CoxA16（+）	EV71 + CoxA16（+）
< 6个月	6（3/3）	6（4/2）	6（4/2）	3.4	4.0	4.1
6个月～	40（25/15）	22（13/9）	21（12/9）	16.2	14.8	14.4
1岁～	143（98/45）	85（57/28）	83（55/28）^a	57.9	57.0	56.8
2岁～	38（23/15）	22（13/9）	22（13/9）	15.4	14.8	15.1
3岁～	13（6/7）	7（4/3）	7（4/3）	5.3	4.7	4.8
≥ 5岁	7（4/3）	7（4/3）	7（4/3）	2.8	4.7	4.8
合计	247（159/88）	149（95/54）	146（92/54）^b	100.0	100.0	100.0

年龄	例数（男/女）			构成比（%）
年龄	EV71（+）	CoxA16（+）	EV71 + CoxA16（+）	EV71（+）	CoxA16（+）	EV71 + CoxA16（+）
< 6个月	6（3/3）	6（4/2）	6（4/2）	3.4	4.0	4.1
6个月～	40（25/15）	22（13/9）	21（12/9）	16.2	14.8	14.4
1岁～	143（98/45）	85（57/28）	83（55/28）^a	57.9	57.0	56.8
2岁～	38（23/15）	22（13/9）	22（13/9）	15.4	14.8	15.1
3岁～	13（6/7）	7（4/3）	7（4/3）	5.3	4.7	4.8
≥ 5岁	7（4/3）	7（4/3）	7（4/3）	2.8	4.7	4.8
合计	247（159/88）	149（95/54）	146（92/54）^b	100.0	100.0	100.0

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