Advances on researching of subacute sclerosing panencephalitis

doi:10.3877/cma.j.issn.1674-1358.2017.03.001

Abstract

Abstract:

Sclerosing panencephalitis (SSPE) is a kind of rare and severe disease, which was mostly developed from infant patients infected with measles virus (MV). The causes of SSPE were related to autoimmunodeficiency of patients and variation of MV, then leading to the infection of brain which lasts for a long period, and the injury of central nervous system is irreversible. The clinical symptoms include intellective degeneration, language disorder, epilepsy and so on. The patients also occur abnormality of electroencephalogram, imageology and antibody of measles virus. Vaccine inoculation has made the incidence decrease of SSPE significantly. The therapeutic methods are focused on inhibition of MV and elevation the patients’ immunity. Unfortunately, new therapies of this disease are still in exploration.

Key words: Subacute sclerosing panencephalitis (SSPE), Measles virus, Immune deficiency, Virus mutation

Cunjun Hou, Zhiying Shao, Xiao Zhao. Advances on researching of subacute sclerosing panencephalitis[J]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2017, 11(03): 209-212.

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