Advances on the effects of angiotensin converting enzyme 2 in coronavirus induced lung injury and other lung diseases

doi:10.3877/cma.j.issn.1674-1358.2021.01.002

Abstract

Abstract:

Angiotensin converting enzyme 2 (ACE2) is considered as an critical regulator of angiotensin converting enzyme-angiotensin Ⅱ (ACE-Ang Ⅱ). The process that ACE2 bound the spike protein (S protein) on the surface of severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) or severe acute respiratory syndrome (SARS) virus, which mediated these virus entrance to target cell for replication and cytotoxic effect were summarized. Furthermore, the possibility of metformin and angiotension converting enzyme inhibitors/angiotensin receptor blockers (ACEI/ARB) to the improvement of the lung tissue damage induced by SARS-CoV-2 were investigated. Additionally, the research progress of ACE2 and Ang Ⅱ hydrolysates-- Ang (1-7) on acute lung injury (ALI), pulmonary fibrosis and pulmonary artery hypertension (PAH) were reviewed. ACE2 played an important role in the pathogenesis of new coronavirus pneumonia and could be an important target for the design and development of drugs for coronavirus disease 2019.

Key words: Angiotensin converting enzyme 2, Severe acute respiratory syndrome-coronavirus 2, Severe acute respiratory syndrome, Inflammation

Fenfen Sun, Binfeng He, Yong He. Advances on the effects of angiotensin converting enzyme 2 in coronavirus induced lung injury and other lung diseases[J]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2021, 15(01): 7-10.

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