Progress on fungal vertebral osteomyelitis

doi:10.3877/cma.j.issn.1674-1358.2021.01.003

Abstract

Abstract:

With the increasing number of immunocompromised patients, the incidence of fungal vetebral osteomyelitis was higher. The epidemiology, diagnosis and treatment of this disease received growing attention. Fungal osteomyelitis was a rare disease, with high rates of misdiagnosis, missed diagnosis and delayed diagnosis, which is closely related to the risk of death. However, the specificity of culture currently is very difficult to identify fungal species. Non-operative measures remain the primary curative modality, which is still controversial because of drug resistance and high frequency of recurrence. The research progress of spinal fungal infection was reviewed and some references for clinical diagnosis and treatment were provided in this article.

Key words: Spine, Fungus, Infection

Zhongyang Xu, Chaoliang Lv, Gongbiao Lu, Jishou Lu. Progress on fungal vertebral osteomyelitis[J]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2021, 15(01): 11-14.

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病例	参考文献	年龄（岁）	性别	延迟诊断（d）	危险因素	脊柱节段	病原体	治疗药物	手术
1	文献^[33]	70	男	35	未发现	T2-T4	曲霉菌	唑类12周	CT引导下穿刺活检
2	文献^[33]	43	男	42	未发现	L1-2	念珠菌	唑类12周	CT引导下穿刺活检
3	文献^[30]	76	男	90	H7N9肺部感染	L5-S1	念珠菌	氟康唑16周	后路清创融合术
4	文献^[15]	59	男	150	胃大部切除术，深静脉置管	T10-T11	不详	规范抗真菌治疗	未手术
5	文献^[34]	35	女	240	未发现	T9-T10	曲霉菌	伊曲康唑12周	后路清创融合术
6	文献^[14]	75	男	90	高血压、糖尿病	L5-S1	念珠菌	两性霉素B、氟康唑24周	未手术
7	文献^[35]	32	男	60	未发现	C6-7	念珠菌	氟康唑24周	前后联合清创融合术
8	文献^[9]	19	女	365	慢性肾病、长期皮质激素治疗	L1-2	念珠菌	两性霉素B及氟康唑12周	后路清创融合术
9	文献^[11]	25	男	180	未发现	L2-L5	曲霉菌	伊曲康唑12周	未手术

病例	参考文献	年龄（岁）	性别	延迟诊断（d）	危险因素	脊柱节段	病原体	治疗药物	手术
1	文献^[33]	70	男	35	未发现	T2-T4	曲霉菌	唑类12周	CT引导下穿刺活检
2	文献^[33]	43	男	42	未发现	L1-2	念珠菌	唑类12周	CT引导下穿刺活检
3	文献^[30]	76	男	90	H7N9肺部感染	L5-S1	念珠菌	氟康唑16周	后路清创融合术
4	文献^[15]	59	男	150	胃大部切除术，深静脉置管	T10-T11	不详	规范抗真菌治疗	未手术
5	文献^[34]	35	女	240	未发现	T9-T10	曲霉菌	伊曲康唑12周	后路清创融合术
6	文献^[14]	75	男	90	高血压、糖尿病	L5-S1	念珠菌	两性霉素B、氟康唑24周	未手术
7	文献^[35]	32	男	60	未发现	C6-7	念珠菌	氟康唑24周	前后联合清创融合术
8	文献^[9]	19	女	365	慢性肾病、长期皮质激素治疗	L1-2	念珠菌	两性霉素B及氟康唑12周	后路清创融合术
9	文献^[11]	25	男	180	未发现	L2-L5	曲霉菌	伊曲康唑12周	未手术

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