To investigate epidemiologic characteristics and drug resistance of cases with fungal bloodstream infection, and to provide a theoretical basis for diagnosis of clinical fungal bloodstream infection and early rational drug use.

The bacterial distribution, department distribution and drug sensitivity of patients with fungal bloodstream infection from January 2016 to December 2018 in Wuhan University People’s Hospital were analyzed, retrospectively.

Total of 192 strains of fungi were isolated from blood culture-positive specimens of 192 patients, among which, Candida albicans had the highest detection rate [31.77% (61/192)], following by Candida tropicalis [18.75% (36/192)]. The department with the highest detection rate of fungal bloodstream infection was ICU [33.85% (65/192)]. All strains were sensitive to amphotericin B. The resistance rate of the other four major antibiotics were 5-fluorocytosine [4.49% (9/192)], itraconazole [5.73% (11/192)], fluconazole [10.94% (21/192)] and voriconazole [11.46% (22/192)]. Except for amphotericin B, the resistance rates of fungi to other antimicrobial agents increased year by year from 2016 to 2018, and the resistance rate of Candida smooth to itraconazole reached 46.7% in 2018.

Candida albicans was the main pathogen of fungal bloodstream infection in our hospital. The antifungal drugs had high sensitivity, but the drug resistance rate was increasing year by year. Therefore, it was very important to strengthen monitoring of the changes of blood culture pathogens and the trend of drug resistance, which was important to guide clinical medication.