Difference of biochemical and routine indexes of cerebrospinal fluid of intracranial infection of critically ill patients in neurology department casused by different pathogenic bacteria

doi:10.3877/cma.j.issn.1674-1358.2018.06.015

Abstract

Abstract:

Objective

To investigate the biochemical and routine indexes of cerebrospinal fluid (CSF) of patients with intracranial infection caused by different pathogens, and to provide theoretical basis for the treatment of intracranial infection.

Methods

From January 2013 to January 2018, a total of 106 critically ill patients in the Department of Neurology were selected from Kaizhou District People’s Hospital of Chongqing, including 59 patients with intracranial infection, while 47 cases with non-intracranial infection were taken as control group. Patients in the research group were divided into two groups according to whether had coma or not: uncoma group (38 cases) and coma group (21 cases). According to the type of infection, patients in the research group were divided into suppurative group (21 cases), tuberculous group (20 cases) and viral group (18 cases). The levels of procalcitonin (PCT), C-reactive protein (CRP) and neuron-specific enolase (NSE) in cerebrospinal fluid and blood supernatant were measured by biochemical analyzer, ELISA method and rate scattering immunoturbidimetry.

Results

The levels of PCT, CRP and NSE in CSF and serum of suppurative group, tuberculous group and viral group were significantly higher than those of control group (all P < 0.05). The NSE levels of serum and CSF in viral group [(15.68 ± 6.15) μg/L and (17.06 ± 3.25) μg/L)] were significantly higher than those of suppurative group [(11.36 ± 3.54) μg/L and (10.65 ± 3.61) μg/L] and tuberculous group [(12.63 ± 4.26) μg/L and (12.89 ± 4.33) μg/L)] (all P < 0.05). The levels of PCT in serum and CSF of patients in suppurative group [(0.86 ± 0.34) ng/ml and (0.72 ± 0.33) ng/ml] and levels of CRP [(8.55 ± 2.4) ng/ml and (8.68 ± 2.57) ng/ml] were significantly higher than that in viral group and tuberculous group (all P < 0. 05). The levels of PCT, CRP and NSE in cerebrospinal fluid and serum of patients in coma group were significantly higher than those of uncomatose group and control group (all P < 0. 05).

Conclusions

The levels of cerebrospinal fluid (CSF) and serum PCT, CRP and NSE in patients with intracranial infection could reflect the condition of intracranial infection and provide reliable basis for the diagnosis and treatment of intracranial infection.

Key words: Intracranial infection, Cerebrospinal fluid, Pathogenic bacteria, Serum

Xu Pan, Ming Li. Difference of biochemical and routine indexes of cerebrospinal fluid of intracranial infection of critically ill patients in neurology department casused by different pathogenic bacteria[J]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2018, 12(06): 601-606.

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References 25

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组别	例数	男/女（例）	年龄（±s，岁）	体质量（±s，kg/m²）	病程（±s，月）
研究组	59	33/26	52.3 ± 12.2	21.6 ± 2.2	3.1 ± 1.3
对照组	47	26/21	52.6 ± 11.9	22.8 ± 2.4	2.9 ± 1.1
统计量	?	χ² = 2.989	t = 2.768	t = 2.243	t = 3.027
P值	?	0.681	0.775	0.597	0.934

组别	例数	男/女（例）	年龄（±s，岁）	体质量（±s，kg/m²）	病程（±s，月）
研究组	59	33/26	52.3 ± 12.2	21.6 ± 2.2	3.1 ± 1.3
对照组	47	26/21	52.6 ± 11.9	22.8 ± 2.4	2.9 ± 1.1
统计量	?	χ² = 2.989	t = 2.768	t = 2.243	t = 3.027
P值	?	0.681	0.775	0.597	0.934

组别	例数	PCT（ng/ml）	NSE（μg/L）	CRP（ng/ml）
化脓性组	21	0.86 ± 0.34^a	11.36 ± 3.54^a	8.55 ± 2.43^a
结核性组	20	0.34 ± 0.18^ab	12.63 ± 4.26^ab	5.54 ± 1.42^ab
病毒性组	18	0.27 ± 0.13^abc	15.68 ± 6.15^abc	3.91 ± 0.96^abc
对照组	47	0.18 ± 0.07	5.50 ± 2.34	1.86 ± 0.51
F值	?	5.236	7.398	2.823
P值	?	0.008	0.003	0.011

组别	例数	PCT（ng/ml）	NSE（μg/L）	CRP（ng/ml）
化脓性组	21	0.86 ± 0.34^a	11.36 ± 3.54^a	8.55 ± 2.43^a
结核性组	20	0.34 ± 0.18^ab	12.63 ± 4.26^ab	5.54 ± 1.42^ab
病毒性组	18	0.27 ± 0.13^abc	15.68 ± 6.15^abc	3.91 ± 0.96^abc
对照组	47	0.18 ± 0.07	5.50 ± 2.34	1.86 ± 0.51
F值	?	5.236	7.398	2.823
P值	?	0.008	0.003	0.011

组别	例数	PCT（ng/ml）	NSE（μg/L）	CRP（ng/ml）
化脓性组	21	0.94 ± 0.38^a	10.65 ± 3.61^a	8.68 ± 2.57^a
结核性组	20	0.41 ± 0.23^ab	12.89 ± 4.33^ab	5.63 ± 1.51^ab
病毒性组	18	0.28 ± 0.15^abc	17.06 ± 3.25^abc	3.79 ± 0.97^abc
对照组	47	0.14 ± 0.03	5.12 ± 1.44	1.97 ± 0.57
F值	?	6.872	4.855	5.761
P值	?	0.007	0.016	0.010

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