To investigate the difference of Mycoplasma types and drug susceptibility in Mycoplasma infection among male and female urogenital patients in our district.

Total of 4 957 patients suspecting urogenital Mycoplasma infection from three hospitals in Longhua District of Shenzhen from January 2014 to December 2016 were collected, including 2 435 male cases and 2 522 female cases. The results of Mycoplasma examination of all patients and the drug sensitivity were analyzed, retrospectively.

Among the 4 957 patients, 2 280 cases were positive with Mycoplasma, the positive rate was 46.0%; and 673 cases (29.5%) were carried by pathogens, 1 607 cases (70.5%) were infected. The positive rates of Mycoplasma in different years were significantly different (all P < 0.05), and the positive rate of Mycoplasma increased year by year. The positive rates of Mycoplasma among patients of different age groups were significantly different. The infection proportion of Ureaplasma urealyticum (Uu) of male patients was significantly higher than that in female patients; but the infection proportion of Mycoplasma hominis (Mh + Uu) in male patients was significantly lower than that of female patients (all P < 0.01). There was no significant difference in the proportion of Mh among male and female patients (P > 0.05), respectively. The drug sensitivity of Mycoplasma to pristinamycin, josamycin and doxycycline were 90.6%, 76.9% and 69.9%, respectively.

The health education mycoplasma infection of urogenital system to female patients aged from 21 to 40 years old should be strengthened, and the diagnosis and treatment should be based on mycoplasma culture and drug susceptibility test, and drugs should be selected according to the diagnosis.