Five cases of infants lichen scrofulosorum

doi:10.3877/cma.j.issn.1674-1358.2017.04.011

Abstract

Abstract:

Objective

To investigate the clinical and pathological characteristics of five infants with lichen scrofulosorum (LS).

Methods

The clinical and pathological data of 5 outpatients of infants with LS who were admitted to Beijing Children’s Hospital, Capital Medical University from 2015 to 2016 were analyzed, retrospectively.

Results

After receiving Bacillus Calmette Guerin (BCG) vaccinations, all patients presented with tiny, skin-coloured to erythematous perifollicular papules over the trunk and extremities, with scales on the surface. All 5 patients showed negative results for tuberculosis infection and immune deficiency tests. Histopathologic examination of 5 patients showed distinctive features, including the epidermal granuloma in the upper-dermis, usually in the vicinity of hair follicles and suboriferous, which were composed of epithelioid cells with a few Langhans giant cells and lymphocytes at the periphery.

Conclusions

Lichen scrofulosorum of 5 patients resolved spontaneously in half a year without any treatment, excluding 1 case with hyperpigmentation on the chest.

Key words: lichen scrofulosorum, Bacillus Calmette Guerin (BCG), Children

Bin Zhang, Shan Wang, Yan Chu, Lin Ma, Zigang Xu, Huan Xing. Five cases of infants lichen scrofulosorum[J]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2017, 11(04): 368-372.

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References 26

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病例	性别	年龄	病程	并发症	皮损分布	皮损形态
1	女	3个月3 d	30 d	无	腹部	与毛囊一致的粟粒大小丘疹，平顶，呈蛙卵状簇集分布，可见皮损消退后轻度萎缩性斑点
2	女	5个月	3 d	特应性皮炎	前胸	与毛囊一致的针尖至粟粒大小淡红色丘疹，成簇分布并融合趋势，少数丘疹顶端覆少许细小鳞屑
3	女	3个月17 d	14 d	婴儿血管瘤	腹部	与毛囊一致针尖至粟粒大小皮色丘疹，单个散在分布
4	女	4个月21 d	90 d	无	前胸、腹部、后背、四肢	粟粒大小淡红色丘疹，成簇分布，部分发展皮色萎缩性斑片，表面可见稍凹陷
5	男	3个月5 d	5 d	传染性软疣	左上臂	针尖大小皮色丘疹，成簇分布，表面干燥，少部分丘疹顶端覆少许细小鳞屑

病例	性别	年龄	病程	并发症	皮损分布	皮损形态
1	女	3个月3 d	30 d	无	腹部	与毛囊一致的粟粒大小丘疹，平顶，呈蛙卵状簇集分布，可见皮损消退后轻度萎缩性斑点
2	女	5个月	3 d	特应性皮炎	前胸	与毛囊一致的针尖至粟粒大小淡红色丘疹，成簇分布并融合趋势，少数丘疹顶端覆少许细小鳞屑
3	女	3个月17 d	14 d	婴儿血管瘤	腹部	与毛囊一致针尖至粟粒大小皮色丘疹，单个散在分布
4	女	4个月21 d	90 d	无	前胸、腹部、后背、四肢	粟粒大小淡红色丘疹，成簇分布，部分发展皮色萎缩性斑片，表面可见稍凹陷
5	男	3个月5 d	5 d	传染性软疣	左上臂	针尖大小皮色丘疹，成簇分布，表面干燥，少部分丘疹顶端覆少许细小鳞屑

病例	PPD	ESR	T-SPOT.TB	胸片	CDs/Igs	皮肤病理
1	N	N	N	N	N	A
2	ND	N	N	N	N	A
3	N	N	N	N	N	A+B
4	N	N	N	N	N	A
5	ND	N	N	N	N	A

病例	PPD	ESR	T-SPOT.TB	胸片	CDs/Igs	皮肤病理
1	N	N	N	N	N	A
2	ND	N	N	N	N	A
3	N	N	N	N	N	A+B
4	N	N	N	N	N	A
5	ND	N	N	N	N	A

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