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Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition) ›› 2017, Vol. 11 ›› Issue (02): 121-124. doi: 10.3877/cma.j.issn.1674-1358.2017.02.004

• Review • Previous Articles     Next Articles

Advances of interleukin-26 in infectious diseases

Zhenhua Sun1, Chao Wu1,()   

  1. 1. Department of Infectious Diseases, Nanjing Drum Tower Hospital, Nanjing Medical University, Nanjing 210008, China
  • Received:2016-04-21 Online:2017-04-15 Published:2021-09-08
  • Contact: Chao Wu

Abstract:

Interleukin (IL)-26, a member of the IL-10 cytokine family, was first discovered by Knappe from herpesvirus saimiri-transformed T lymphocytes. IL-26 is widely found in vertebrates except for mice. Activated T cells, natural killer cells and macrophages are the main sources of IL-26. IL-26 is located on chromosome 12q15 between the genes for other two important cytokines, interferon (IFN)-γ and IL-22. IL-26 receptor is a heterodimeric receptor complex which is composed of two class Ⅱ cytokine receptors, IL-20 receptor 1 and IL-10 receptor 2. In recent years, the biological functions of IL-26 have been extensively studied. IL-26 was found to play an important role in the development of psoriasis, inflammatory bowel diseases, systemic sclerosis and rheumatoid arthritis, and associated with the severity of the diseases. In infectious diseases, IL-26 plays a proinflammatory role and may participate in promoting pathogens clearance or maintaining persistent infection of pathogens. This review will focus on the advances of IL-26 in infectious diseases.

Key words: Interleukin-26, Infectious diseases, Biological functions

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