To investigate the clinical distribution and drug resistance of Acinetobacter baumannii (AB) infection, which could indicate the rational using of antibacterial drugs.

The drug susceptibility for 1 089 strains of AB separated from clinical specimens from 2012 to 2015 in No. 1 People’s Hospital were collected.

Total of 1 089 strains of AB were detected during the 4 years. The cases of multiple drug resistance (MDR) AB isolated from patients in intensive care unit (ICU) were 166 strains (69.7%), 133 strains (64.8%), 163 strains (76.1%) and 143 strains (71.8%) in 2012, 2013, 2014 and 2015, respectively, and the cases in non-ICU patients were 28 strains (51.9%), 21 strains (40.4%), 24 strains (35.8%) and 15 strains (25.0%), respectively. About 83.7% specimens were originated from sputum. Among the AB strains detected, the MDR-AB accounted for 63.63%. There were 861 strains originated from ICU, accounting for 79.1% of all infection wards and the department of respiratory medicine ranked the second with 125 strains (11.5%). The results of drug-resistant test showed that more than 40% of AB were resistant to many antibacterial drugs except for minocycline.

The phenomenon of drug resistance with AB was serious, especially in ICU. So, bacterial culture and drug-resistant test should be paied attention, we should choose proper antibiotics and complete the prevention monitoring, which could effectively decrease the occurrence of the bacterial drug resistance.