New progress of the influence factors of mother-to-child transmission of chronic hepatitis B

doi:10.3877/cma.j.issn.1674-1358.2016.03.003

Abstract

Abstract:

HBV is mainly transmitted via mother-to-child transmission (MTCT), combined immunization (HBIG + hepatitis B vaccination) had reduced 90%-95% newborns MTCT, but for mothers of high viral load, there were still 8%-32% newborns infected with HBV. Over 90% of perinatally acquired infections progress to chronic HBV infection. There were 15%-25% of these chronic infected people will die of cirrhosis or liver cancer eventually. Therefore, the management of HBsAg-positive pregnant women and the strategy of blocking MTCT are crucial to reduce the MTCT rate. Due to the sensitivity of such problems, clinical trials are difficult. Here, the routes of transmission and influencing factors of MTCT were overviewed.

Key words: Chronic hepatitis B, Mother-to-child transmission mode, Influencing factors

Min Yang, Yingxia Liu. New progress of the influence factors of mother-to-child transmission of chronic hepatitis B[J]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2016, 10(03): 265-268.

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