Meta-analysis of piperacillin/tazobactam and cefoperazone/sulbactam for bacterial infection

doi:10.3877/cma.j.issn.1674-1358.2016.03.004

Abstract

Abstract:

Objective

To evaluate the efficiency and safety of piperacillin/tazobactam and cefoperazone/sulbactam.

Methods

Eight randomized control trials comparing the effect of treatment between piperacillin/tazobactam and cefoperazone/sulbactam were retrieved through the four Chinese database and foreign language periodicals database. The data of these articles were processed with Meta analysis by RevMan 5.3 and Stata 12.1 softwares.

Results

The data were statistically analyzed by the fixed effects model, the pooled odds ratio [OR (95%CI)] of the cure rates, eficacy rates, adverse reaction rates and adverse reactions rates of piperacillin/tazobactam and cefoperazone/sulbactam for bacterialinfection were 0.91 (0.62-1.33), 1.00 (0.60-1.67), 1.00 (0.60-1.67) and 1.85 (1.05-3.26), respectively, the combined effect of P were 0.62, 0.99, 0.61 and 0.03. The results showed that P = 0.90, 95%CI: -0.59-0.66 by the Egger linear regression method.

Conclusion

Piperacillin/tazobactam and cefoperazone/sulbactam had the same safety and efficiency.

Key words: Piperacillin/tazobactam, Cefoperazone/sulbactam, Bacterial infection, Meta-analysis

Guofeng Mao, Er Xu. Meta-analysis of piperacillin/tazobactam and cefoperazone/sulbactam for bacterial infection[J]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2016, 10(03): 269-273.

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References 25

1	李静，张素花. 头孢哌酮舒巴坦在老年呼吸系统感染性疾病中的应用[J]. 山东医药,2013,53(29):98-99.
2	Ning F, Shen Y, Chen X, et al. A combination regimen of meropenem, cefoperazone-sulbactam and minocycline for extensive burns with pan-drug resistant Acinetobacter baumannii infection[J]. Chin Med J,2014,127(6):1177-1179.
3	Xia J, Zhang D, Xu Y, et al. A retrospective analysis of carbapenem-resistant Acinetobacter baumannii-mediated nosoconial pneumonia and the in vitro therapeutic benefit of cefoperazone/sulbactam[J]. Int J Infect Dis,2014,23(1):90-93.
4	陈岐辉，柳宏林，王晓庆, 等. 哌拉西林/他唑巴坦治疗泌尿系感染210例临床分析[J]. 中华医院感染杂志,2012,22(13):2905-2907.
5	陈岐辉，张英，卢绩, 等. 哌拉西林/他唑巴坦治疗尿道狭窄合并感染150例分析[J]. 中华医院感染杂志,2012,19(23):3241-3243.
6	郑碧霞，程德云，杨莹, 等. 哌拉西林/他唑巴坦对中重度下呼吸道感染的治疗效果[J]. 四川大学学报(医学版),2007,38(5)910-911.
7	谢志伟，黄建军，黄旭强, 等. 哌拉西林/他唑巴坦与头孢哌酮/舒巴坦治疗儿童中重度细菌性肺炎的疗效观察[J]. 中华医院感染杂志,2012,22(4):806-808.
8	聂为民，涂波，张昕, 等. 抗菌药物治疗自发性细菌性腹膜炎临床疗效评价[J]. 中华医院感染杂志,2012,24(10):2433-2435.
9	李媛，靳学雷. 哌拉西林/他唑巴坦在中重度呼吸道感染中的疗效与安全性观察[J]. 中华医院感染杂志,2013,23(15):3732-3733.
10	夏勤，符馨尹. 2012年2月-2013年2月某院50例铜绿假单胞菌和不动杆菌泛耐药,全耐药患者的治疗分析[J]. 中国药房,2013,24(42):3981-3983.
11	吴华，梁剑辉，刘晓青. 哌拉西林/他唑巴坦治疗中重度下呼吸道感染的疗效观察[J]. 中华医院感染杂志,2005,15(5):577-579.
12	文亚坤，曹萌，邹琳, 等. 碳青霉烯类抗生素耐药铜绿假单胞菌的体外联合药敏研究[J]. 中国抗生素杂志,2012,37(7):536-538.
13	Xin X, Jian L, Xia X, et al. A multicentre clinical study on the injection of ceftriaxone/sulbactam compared with cefoperazone/sulbactam in the teratment of respiratory and urinary tract infections[J]. Ann Clin Microbiol Antimicrob,2013,12(1):38.
14	高璇，李静，李智平. 住院儿童单独使用万古霉素或联合哌拉西林/他唑巴坦治疗后的肾毒性比较[J]. 复旦学报(医学版),2015,42(6):743-748.
15	翁贤新. 哌拉西林他唑巴坦治疗医院获得性肺炎的疗效观察[J]. 临床合理用药杂志,2013,6(18):54.
16	蔡挺，叶龙翔. 3种β-内酰胺类抗菌药物延长及持续输注对产ESBLs细菌的药效学研究[J]. 中华医院感染杂志,2010,20(14):2110-2113.
17	何聪，申丽昊，杜全胜, 等. 根据PK/PD理论指导哌拉西林他唑巴坦治疗革兰阴性杆菌感染的临床观察[J]. 临床合理用药,2014,7(10A):41-42.
18	吕扬，闫昭，王东浩, 等. 哌拉西林/他唑巴坦延长输注时间的优化给药方案与传统给药方式用于治疗医院获得性肺炎的研究[J]. 中华危重病急救医学,2013,25(8):479-483.
19	叶龙强，石林惠，董绉绉. 延长头孢哌酮/舒巴坦输注时间治疗重症监护病房　鲍曼不动杆菌肺炎的临床研究[J]. 中华临床感染病杂志,2015,8(2):164-166.
20	柯倩，吕媛，王风娟. 美罗培南联合舒巴坦或头孢哌酮-舒巴坦对多重耐药鲍曼不动杆菌的体外抗菌活性[J]. 中国感染与化疗杂志,2015,15(6):548-551.
21	于亮，王梅. 亚胺培南联合头孢哌酮/舒巴坦对耐碳青霉烯鲍曼不动杆菌的抗菌作用[J]. 中华传染病杂志,2013,31(7):396-398.
22	丁斌斌，张忆敬，白雪梅. 哌拉西林他唑巴坦治疗老年性肺炎疗效观察[J]. 包头医学院学报,2011,27(6):70-71.
23	Karaman S, Vural S, Yildirmak Y, et al. Comparison of piperacillin tazobactam and cefoperazone sulbactam monotherapy in treatment of febrile neutropenia[J]. Pediatr Blood Cancer,2012,58(4):579-583.
24	李学军，亓秀静，杨逢永. 头孢哌酮/舒巴坦治疗下呼吸道感染的疗效分析[J]. 中华医院感染学杂志,2014,24(16):3961-3963.
25	贾书冰，赵明沂，梁露花. 漏斗图在Meta分析中的正确使用研究[J]. 数理医药学杂志,2013,26(4):402-405.

作者	年份	PIP/TAZ					CFP/SBT					Jadad评分
作者	年份	治愈例数	有效例数	不良反应例数	总例数	清除率[例（%）]	治愈例数	有效例数	不良反应例数	总例数	清除率[例（%）]	Jadad评分
陈岐辉^[4]	2012	112	136	0	156	103/119（86.6）	39	47	0	54	33/38（86.8）	3
陈岐辉^[5]	2009	92	112	0	126	88/97（90.7）	19	22	0	24	15/16（93.8）	3
郑碧霞^[6]	2007	—	30	3	33	22/25（88.0）	—	27	5	30	12/14（85.7）	3
谢志伟^[7]	2012	22	27	2	30	9/10（90.0）	20	25	1	30	8/18（44.4）	2
聂为民^[8]	2014	9	28	2	33	—	17	31	1	32	—	3
李缓^[9]	2013	20	32	2	35	31/35（88.6）	17	29	4	35	24/35（68.6）	2
夏勤^[10]	2013	—	3	—	5	—	—	7	—	11	—	2
吴华^[11]	2005	20	27	2	30	29/32（90.6）	19	27	2	30	27/32（84.4）	2

作者	年份	PIP/TAZ					CFP/SBT					Jadad评分
作者	年份	治愈例数	有效例数	不良反应例数	总例数	清除率[例（%）]	治愈例数	有效例数	不良反应例数	总例数	清除率[例（%）]	Jadad评分
陈岐辉^[4]	2012	112	136	0	156	103/119（86.6）	39	47	0	54	33/38（86.8）	3
陈岐辉^[5]	2009	92	112	0	126	88/97（90.7）	19	22	0	24	15/16（93.8）	3
郑碧霞^[6]	2007	—	30	3	33	22/25（88.0）	—	27	5	30	12/14（85.7）	3
谢志伟^[7]	2012	22	27	2	30	9/10（90.0）	20	25	1	30	8/18（44.4）	2
聂为民^[8]	2014	9	28	2	33	—	17	31	1	32	—	3
李缓^[9]	2013	20	32	2	35	31/35（88.6）	17	29	4	35	24/35（68.6）	2
夏勤^[10]	2013	—	3	—	5	—	—	7	—	11	—	2
吴华^[11]	2005	20	27	2	30	29/32（90.6）	19	27	2	30	27/32（84.4）	2

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