To investigate the types, distribution and effect factors of pathogenic bacteria in patients with diabetic foot infection recurrence.

Total of 185 patients with diabetic foot in our hospital from October 2013 to January 2015 were collected. The routine bacterial culture and drug sensitive test of specimens of 106 patients with infection recurrence were detected, and the related factors of diabetic foot infection recurrence were analyzed.

There were 127 pathogenic bacterias cultured, with 54.7% of Gram-positive bacteria, 39.5% of Gram-negative bacteria and 5.8% of others. The drug resistance rate of Gram-positive bacterium to vancomycin and Gram-negative bacteria to panipenem were both low. The results of multivariate Logistic regression analysis showed that diabetic foot infection recurrence and the multiple drug-resistant of bacterias were releated with antibiotics recently using, the healing time of ulcer longer than 65 days and peripheral vascular diseases (P = 0.0268, 0.0058 and 0.0045).

A variety of pathogenic bacteria infection is the main reason which leads to diabetic foot infection recurrence, most of them have a certain drug resistance to the antimicrobial agents, therefore, the use of antibiotics should be controled strictly; multiple drug-resistant pathogens, the healing time of ulcer longer than 65 days and peripheral vascular disease could increase infection recurrence risk, which should be closely monitored and early clinical intervened.