Abstract:

Objective

To improve clinical understanding of reactive infectious skin and mucous membrane rash （RIME） caused by Mycoplasma pneumoniae infection， and to provide more accurate treatment and prognosis assessment for this disease.

Methods

A retrospective analysis was conducted on clinical data，treatment and prognosis of a patient with RIME caused by Mycoplasma pneumoniae infection， who was admitted to the Zhejiang University Sir Run Run Shaw Alaer Hospital， on April 11th， 2024.

Results

The 15-year-old female patient presented with symptoms indicative of fever， cough and mucosal ulceration.Subsequent laboratory investigations revealed the presence of positive serum IgM antibodies to Mycoplasma pneumoniae and a positive result for a Mycoplasma pneumoniae DNA amplification test conducted on throat swabs. Chest computed tomography （CT） scan revealed the presence of multiple patchy opacities， which were consistent with the imaging characteristics of Mycoplasma pneumoniae pneumonia. Throughout the clinical course， the patient exhibited a constellation of cutaneous lesions， including vesicular eruptions， targetoid lesions and mucocutaneous ulcerations. The diagnosis of RIME was supported by the combined evidence of laboratory findings indicative of a Mycoplasma pneumoniae infection. The patient was treated with doxycycline for its antibacterial properties， in conjunction with a brief course of moderate-dose corticosteroids and intravenous immunoglobulin therapy. This resulted in a complete recovery and subsequent discharge from the hospital.

Conclusions

RIME caused by Mycoplasma pneumoniae infection can be effectively managed with doxycycline， corticosteroids and immunoglobulin therapy， with a favorable prognosis.

Key words: Mycoplasma pneumoniae, Pneumonia, Rash, Mucositis