Advances in antiviral study on interferon-induced transmembrane protein

doi:10.3877/cma.j.issn.1674-1358.2018.03.002

Abstract

Abstract:

Interferon-induced transmembrane proteins (IFITMs), a class of novel discovered viral restriction factors, are widely expressed in human tissue cells, mainly located in plasma membrane and endolysosomal comparments, which are the main targets of the virus entry. By inhibiting membrane fusion between virus and cell membrane, IFITMs restrict the entry of a broad spectrum of viruses, including Ebola virus, influenza A virus, severe acute respiratory syndromes (SARS) coronavirus, dengue virus, West Nile virus and Zika virus. Although IFITM has been shown to be able to suppress the infection of virus of the eight virus families, and it primarily inhibits the fusion process of the virus entry stage, but the mechanism of IFITM antiviral activity remains unknown. In recent years, the antiviral effect of IFITM and its mechanism has become a hotspot in related fields. Here the recent advance of IFITM’s antiviral spectrum and underlying mechanism of how these proteins exert antiviral function were reviewed.

Key words: Interferon-induced transmembraneprotein, Viral entry, Membrane fusion

Zhifei Hou, Xuesen Zhao. Advances in antiviral study on interferon-induced transmembrane protein[J]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2018, 12(03): 212-215.

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References 26

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基因名称	诱导类型	细胞定位	主要表达细胞	作用机制	抑制主要病毒	促进病毒
IFITM1	Ⅰ型IFN、Ⅱ型IFN	细胞膜	上皮细胞、内皮细胞	抑制病毒与细胞膜融合	HCV、PIV3、SARS-CoV、MARV、EBOV、DNV、IAV、HIV、WNV	无
IFITM2	Ⅰ型IFN、Ⅱ型IFN	可能早期内体、晚期内体、溶酶体	上皮细胞、内皮细胞	抑制病毒与细胞膜融合	MERS-CoV、SARS-CoV、VSV、IAV、MARV、EBOV、DNV、WNV、HIV	HCoV-OC43
IFITM3	Ⅰ型IFN、Ⅱ型IFN	早期内体、晚期内体、溶酶体	上皮细胞、内皮细胞	抑制病毒与细胞膜融合	MERS-CoV、SARS-CoV、VSV、IAV、MARV、EBOV、DNV、WNV、HIV	HCoV-OC43

基因名称	诱导类型	细胞定位	主要表达细胞	作用机制	抑制主要病毒	促进病毒
IFITM1	Ⅰ型IFN、Ⅱ型IFN	细胞膜	上皮细胞、内皮细胞	抑制病毒与细胞膜融合	HCV、PIV3、SARS-CoV、MARV、EBOV、DNV、IAV、HIV、WNV	无
IFITM2	Ⅰ型IFN、Ⅱ型IFN	可能早期内体、晚期内体、溶酶体	上皮细胞、内皮细胞	抑制病毒与细胞膜融合	MERS-CoV、SARS-CoV、VSV、IAV、MARV、EBOV、DNV、WNV、HIV	HCoV-OC43
IFITM3	Ⅰ型IFN、Ⅱ型IFN	早期内体、晚期内体、溶酶体	上皮细胞、内皮细胞	抑制病毒与细胞膜融合	MERS-CoV、SARS-CoV、VSV、IAV、MARV、EBOV、DNV、WNV、HIV	HCoV-OC43

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