Correlation of ureaplasma urealyticum infection and cervical intraepithelial neoplasm

doi:10.3877/cma.j.issn.1674-1358.2016.06.018

Abstract

Abstract:

Objective

To investigate the correlation of ureaplasma urealyticum (Uu) infection and cervical intraepithelial neoplasm (CIN).

Methods

Total of 110 CIN patients diagnosed by pathology in our hospital from September 2012 to April 2015 were selected, including 48 cases of CIN Ⅰ, 40 cases of CIN Ⅱ and 22 cases of CIN Ⅲ. All the CIN patients were followed-up for 3 years, 85 cases (77.27%) were not cancerous, but the other 25 cases (22.73%) developed to cervical cancer, while 110 healthy volunteers were selected as control group. The correlation of Uu infection and cervical intraepithelial neoplasm was analyzed.

Results

The rates of Uu infection in different levels of CIN patients were compared, cases with CIN Ⅰ, CIN Ⅱ and CIN Ⅲ were significantly more than cases without Uu infection (χ² = 6.000, 16.200, 5.818; P = 0.01, 0.00, 0.02). The Uu infection rate of patients with CIN Ⅰ, CIN Ⅱ and CIN Ⅲ were all significantly higher than that of the control group (χ² = 9.251, 15.421, 7.636; P = 0.01, 0.00, 0.01). The rate of Uu infection in patients with cervical cancer was higher than that of patients without cancer, with significant difference (χ² = 4.112, P = 0.043).

Conclusions

There was significant correlation between Uu infection and CIN, and reduction of Uu infection was benefitial to control the occurrence and development to cancer of CIN.

Key words: Ureaplasma urealyticum, Cervical intraepithelial neoplasm, Infection rate

Aiping Chen. Correlation of ureaplasma urealyticum infection and cervical intraepithelial neoplasm[J]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2016, 10(06): 733-735.

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References 21

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组别	例数	感染Uu	未感染Uu	χ²值	P值
CIN Ⅰ组	48	30（62.5）	18（37.5）	6.000	0.01
CIN Ⅱ组	40	29（72.5）	11（27.5）	16.200	0.00
CIN Ⅲ组	22	15（68.2）	7（31.8）	5.818	0.02

组别	例数	感染Uu	未感染Uu	χ²值	P值
CIN Ⅰ组	48	30（62.5）	18（37.5）	6.000	0.01
CIN Ⅱ组	40	29（72.5）	11（27.5）	16.200	0.00
CIN Ⅲ组	22	15（68.2）	7（31.8）	5.818	0.02

组别	例数	Uu阳性例数	Uu感染率（%）
CIN Ⅰ组	48	30	62.5^a
CIN Ⅱ组	40	29	72.5^b
CIN Ⅲ组	22	15	68.2^c
对照组	110	40	36.4

组别	例数	Uu阳性例数	Uu感染率（%）
CIN Ⅰ组	48	30	62.5^a
CIN Ⅱ组	40	29	72.5^b
CIN Ⅲ组	22	15	68.2^c
对照组	110	40	36.4

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