A case of prolongable curative course by PegIFN on treating chronic hepatitis B with positive HBsAg and HBsAb

doi:10.3877/cma.j.issn.1674-1358.2016.04.029

Abstract

Abstract:

Objective

To provide better diagnosis and therapy through a retrospective summary of chronic hepatitis B patient with positive HBsAg and HBsAb after interferon therapy.

Methods

The clinical data, treatment and laboratory findings of the patient were analyzed retrospectively.

Results

The sustained HBsAg loss is achieved after discontinuing therapy when the period of Peg-IFN treatment is extended to 108 weeks.

Conclusions

The treatment of chronic hepatitis B is expected to achieve the ideal end point by extending the period of interferon therapy under the guidance of accurate virological and serological detection.

Key words: Chronic hepatitis B, Interferon, Mutation, Case report

Keng Chen, Ruosu Ying, Huiyuan Liu. A case of prolongable curative course by PegIFN on treating chronic hepatitis B with positive HBsAg and HBsAb[J]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2016, 10(04): 510-512.

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URL: https://zhsyhlcgrbzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1674-1358.2016.04.029

https://zhsyhlcgrbzz.cma-cmc.com.cn/EN/Y2016/V10/I04/510

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References 15

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时间（周）	HBsAg		HBsAb （IU/ml）	HBeAg		HBeAb （COI）	HBV DNA （IU/ml）	ALT （U/L）
时间（周）	COI	IU/ml	HBsAb （IU/ml）	COI	PEI U/ml	HBeAb （COI）	HBV DNA （IU/ml）	ALT （U/L）
0^a	6 815	—	842.6	1 080	—	7.61	1.04 × 10⁶	90
12	664.20	78.86	1030	158.60	31.12	1.59	< 500	—
24	430.40	56.01	845.5	12.43	2.83	0.55	< 500	23
36	44.10	14.48	310.6	0.29	阴性	0.01	< 500	28
48	3.77	11.84	1 000	0.07	阴性	0.01	< 500	41
60	0.43	—	1 000	0.06	—	0.07	< 500	28
72	—	11.05	1 000	—	0.02	0.01	< 12	30
84	0.5	—	1 000	—	—	0.01	—	—
96	—	20.00	1 000	—	0.01	0.01	< 500	25
108	0.34	—	1 000	0.08	—	0.01	< 500	22
32b	0.22	0.05	1 000	0.07	0.01		< 500	21
48^b	0.69	—	1 050	0.15	—	0.01	< 500	25
60^b	0.74	—	1 000	0.1	—	0.01	< 500	35
120^b	0.67	—	888.5	0.1	—	0.01	< 500	28

时间（周）	HBsAg		HBsAb （IU/ml）	HBeAg		HBeAb （COI）	HBV DNA （IU/ml）	ALT （U/L）
时间（周）	COI	IU/ml	HBsAb （IU/ml）	COI	PEI U/ml	HBeAb （COI）	HBV DNA （IU/ml）	ALT （U/L）
0^a	6 815	—	842.6	1 080	—	7.61	1.04 × 10⁶	90
12	664.20	78.86	1030	158.60	31.12	1.59	< 500	—
24	430.40	56.01	845.5	12.43	2.83	0.55	< 500	23
36	44.10	14.48	310.6	0.29	阴性	0.01	< 500	28
48	3.77	11.84	1 000	0.07	阴性	0.01	< 500	41
60	0.43	—	1 000	0.06	—	0.07	< 500	28
72	—	11.05	1 000	—	0.02	0.01	< 12	30
84	0.5	—	1 000	—	—	0.01	—	—
96	—	20.00	1 000	—	0.01	0.01	< 500	25
108	0.34	—	1 000	0.08	—	0.01	< 500	22
32b	0.22	0.05	1 000	0.07	0.01		< 500	21
48^b	0.69	—	1 050	0.15	—	0.01	< 500	25
60^b	0.74	—	1 000	0.1	—	0.01	< 500	35
120^b	0.67	—	888.5	0.1	—	0.01	< 500	28

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