Abstract:

Histopathology， bacterial culture or ¹³C/¹⁴C urea breath test are usually considered as the gold standards for diagnosis of Helicobacter pylori （H. pylori） infection. Histologic examination and bacterial culture are invasive， with high technical requirements and long process. Therefore， they are not applicable to children and elderly patients with underlying diseases. ¹³C urea breath test is expensive， ¹⁴C is radioactive and not recommended for children or pregnant women， urea breath test is easily interfered by drugs such as proton pump inhibitors， antibiotics and other drugs. Molecular tests have advantages on strain typing and antibiotic resistance screening， and can use different sample types from both invasive and non-invasive approaches.This article provides a review of the molecular detection techniques for H. pylori.

Key words: Helicobacter pylori, Molecular diagnosis, Detection