To establish an integral assessment diagnostic approach of lung fluke disease (LFD), which based on clinical manifestations, laboratory examination and imaging tests, and to improve the diagnostic level of LFD.

The clinical data of 56 patients with clinically diagnosed LFD in Renmin Hospital of Shiyan City (Renmin Hospital, Hubei University of Medicine) from January 2008 to June 2019 were analyzed, retrospectively. The clinical symptoms, signs, epidemiological history of the patients were recorded; levels of white blood cell (WBC), eosinophil (EOS) count, platelet (PLT) count, serosal cavity effusion index, histopathological examination, sputum smear cytology culture were analyzed, respectively. The nuclear magnetic resonance imaging (MRI), multilayered spiral CT (MSCT), color doppler ultrasound findings were also analyzed, and integration of lung-pulmonary, subcutaneous, cerebrospinal, abdominal symptoms and/or signs at the site of pneumonitis colonization into 2 points per site. With LFD personal history (eating raw crab or crab, drinking raw water) was scored 2 points. WBC 10 × 10⁹/L was scored as 0, increasing 0.1 point for each increased 1 × 10⁹/L. EOS 0.30 × 10⁹/L was scored as 0, increasing 0.1 points for each increased 0.03 × 10⁹/L. Score PLT 300 × 10⁹/L was scored as 0, increasing 0.1 point for each increased 10 × 10⁹/L. The EOS of serous cavity effusion increased and tissue EOS invaded were both scored as 2 points. MRI, MSCT, ultrasound and other detection of chest lung, subcutaneous, spinal cord, abdominal cavity lesions of each organ lesion were all scored as 2 points. Tissue discovery of paragonimus body or eggs, sputum or stool discovery of paragonimus eggs directly was scored as 8 points. The paragonimiasis antigen intradermal test (PAIT) and paragonimiasis antibody test (ELISA-PAb) of paragonimiasis antigen were carried out according to diagnostic criteria of infectious diseases. The sensitivity and specificity of the diagnostic LFD of the "integral diagnostic scale" were analyzed by comparing the positive patients with PAIT and ELISA-PAb, respectively.

According to clinical manifestations (clinical symptoms and signs, personal history), laboratory examination, imaging results, establishment of LFD "integral diagnostic scale " were establishmented. when the patient’s integral diagnostic scale was higher than 9.31, excluding EOS caused by eosinophilia and other related diseases through clinical manifestations (history, physical examination), laboratory examination, imaging examination, pathological examination it could suggest possible LFD. The higher of integral diagnostic scale was, the more possibility likely to LFD. The score of LFD patients was 9.31-25.58. The sensitivity of the diagnostic LFD of integral diagnostic scale was 100% and the specificity was 93.33%.

The diagnostic sensitivity and specificity to LFD of integral diagnostic scale were well and suitable to LFD clinical diagnosis.