To analyze the changes of laboratory indexes of patients with brucellosis at different stages, and to provide clinical reference for the diagnosis and prognosis evaluation of brucellosis.

Total of 45 patients with brucellosis diagnosed in the First people’s Hospital of Tianmen were enrolled, the levels of calcitonin proto (PCT), hypersensitive C-reactive protein (hsCRP), white blood cell (WBC), platelets (PLT), alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatinine (Crea), urinary microalbumin (mALB), erythrocyte sedimentation rate (ESR) positive rate of blood culture and positive rate of tube agglutination test were detected, retrospectively. According to the clinical stages, 45 patients were divided into three groups: acute stage group (23 cases), subacute stage group (8 cases) and chronic stage group (14 cases).

There was no significant difference of WBC, PCT, hsCRP, ALT, Crea and mALB levels between acute stage group and subacute stage group (t_WBC = 2.04, P = 0.082; t_PCT = 1.98, P = 0.093; t_hsCRP = 2.18, P = 0.081; t_ALT = 0.94, P = 0.18; t_Crea = 2.31, P = 0.088; t_mALB = 2.02, P = 0.085). The proportion of AST increase in patients with acute stage brucellosis was significantly lower than that of patients with subacute stage brucellosis (t = 7.59, P = 0.023). The levels of WBC, PCT, hsCRP, ALT, Crea and mALB in patients of acute stage group and chronic stage group were with significant differences (t_WBC = 8.43, P = 0.021; t_PCT = 18.36, P = 0.013; t_hsCRP = 12.35, P = 0.020; t_ALT = 5.38, P = 0.024; t_Crea = 4.81, P = 0.036; t_mALB = 10.87, P = 0.020). There was no significant difference in WBC, PCT, hsCRP, ALT, Crea and mALB levels between patients with subacute stage group and chronic stage group (t_WBC = 1.12, P = 0.096; t_PCT = 2.19, P = 0.082; t_hsCRP = 2.03, P = 0.084). With the prolongation of brucellosis, PLT decreased, ESR increased rapidly and the positive rate of blood culture decreased gradually from acute stage to chronic stage, but the positive rate of tube agglutination test was high. The levels of PCT and hsCRP in patients with brucellosis at different stages were significantly different before and after treatment (t_PCT = 7.85, 16.31, 27.60; P = 0.018, 0.0023, 0.003. t_hsCRP = 9.98, 12.14, 7.88; P = 0.021, 0.036, 0.031).

The changes of laboratory indexes such as WBC, PLT, ALT, AST, Crea and ESR could reflect the dynamic changes of brucellosis. Blood culture and tube agglutination test positive are the diagnostic criteria for brucellosis. PCT and hsCRP could be taken as a reference to monitor the condition and prognosis of patients.