Peripheral immune function of pneumonia infants with cytomegalovirus infection

doi:10.3877/cma.j.issn.1674-1358.2019.02.004

Abstract

Abstract:

Objective

To evaluate the peripheral immune status of pneumonia infants with cytomegalovirus (CMV) infection.

Methods

Total of 154 infants aged 2 to 24 months with pneumonia were recruited from January 2012 to September 2016 in the First Affiliated Hospital of Nanjing Medical University. According to the results of cytomegalovirus pathogen detection, 154 cases were divided into two groups: CMV positive group (90 cases) and CMV negative group (64 cases). The clinical data and laboratory results were analyzed, retrospectively. The peripheral blood cell counts and the hospitalization stay of two groups of children with pneumonia were compared, respectively. According to the parameters of blood cells, the related indexes of systemic inflammatory reaction including neutrophil/lymphocyte (NLR), platelet/lymphocyte (PLR), differences of lymphocyte/monocyte (LMR) and systemic immune inflammatory index (SII) (neutrophil/lymphocyte × platelet) were analyzed, respectively.

Results

Compared with CMV negative group, the counts of peripheral leukocytes [(7.83 ± 2.92) × 10⁹/L vs. (9.59 ± 4.03) × 10⁹/L, Z =-4.291, P < 0.001], monocytes [(0.63 ± 0.35) × 10⁹/L vs. (0.78 ± 0.47) × 10⁹/L; Z =-3.104, P = 0.002], neutrophils [(1.73 ± 1.60) × 10⁹/L vs. (2.64 ± 1.65) × 10⁹/L; Z =-5.017, P < 0.001] and platelets counts [(331.50 ± 140.50) × 10⁹/L vs. (364.00 ± 163.80) × 10⁹/L; Z =-2.013, P = 0.044] of cases in CMV positive group decreased significantly; NLR [(0.35 ± 0.35) vs. (0.51 ± 0.50); Z =-3.388, P < 0.001] and SII [(107.10 ± 133.16) vs. (182.40 ± 173.3); Z = -4.029, P < 0.001] also decreased significantly. The hospitalization stay of cases in CMV-positive group was significantly longer than that of the CMV-negative group [(9.12 ± 2.88) vs. (8.28 ± 1.79) d; χ² =-2.063, P = 0.039], and the proportion of children with hospitalization stay longer than 2 weeks in CMV-positive group was higher than that of CMV-negative group, with significant difference (14.44% vs. 1.56%; χ² = 7.510, P = 0.006).

Conclusions

Peripheral blood immune dysfunction exists in pneumonia infants with cytomegalovirus infection.

Key words: Cytomegalovirus, Infantile pneumonia, Immunologic dysfunction, Neutrophil to lymphocyte ratio, Hospitalization stay

Wenwen Shang, Hong Zhao, Guodong Rong, Lei Wu, Peijun Huang, Fang Wang, Ting Xu. Peripheral immune function of pneumonia infants with cytomegalovirus infection[J]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2019, 13(02): 105-109.

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组别	例数	性别（男/女）	年龄（M ± IQR，月）	身高（M ± IQR，cm）	体重（M ± IQR，kg）
CMV阳性组	90	55/35	6.00 ± 6.00	69.5 ± 8.70	8.87 ± 3.12
CMV阴性组	64	41/23	6.50 ± 6.75	67.2 ± 6.78	8.12 ± 3.12
统计量	?	χ² = 0.139	Z =－0.155	Z =－0.157	Z =－0.169
P值	?	0.710	0.877	0.871	0.783

组别	例数	性别（男/女）	年龄（M ± IQR，月）	身高（M ± IQR，cm）	体重（M ± IQR，kg）
CMV阳性组	90	55/35	6.00 ± 6.00	69.5 ± 8.70	8.87 ± 3.12
CMV阴性组	64	41/23	6.50 ± 6.75	67.2 ± 6.78	8.12 ± 3.12
统计量	?	χ² = 0.139	Z =－0.155	Z =－0.157	Z =－0.169
P值	?	0.710	0.877	0.871	0.783

组别	例数	白细胞	单核细胞	中性粒细胞	血小板	淋巴细胞
CMV阳性组	90	7.83 ± 2.92	0.63 ± 0.35	1.73 ± 1.60	331.50 ± 140.50	4.92 ± 2.48
CMV阴性组	64	9.59 ± 4.03	0.78 ± 0.47	2.64 ± 1.65	364.00 ± 163.80	5.67 ± 2.87
Z值	?	－4.291	－3.104	－5.017	－2.013	－1.324
P值	?	< 0.001	0.002	< 0.001	0.044	0.186

组别	例数	白细胞	单核细胞	中性粒细胞	血小板	淋巴细胞
CMV阳性组	90	7.83 ± 2.92	0.63 ± 0.35	1.73 ± 1.60	331.50 ± 140.50	4.92 ± 2.48
CMV阴性组	64	9.59 ± 4.03	0.78 ± 0.47	2.64 ± 1.65	364.00 ± 163.80	5.67 ± 2.87
Z值	?	－4.291	－3.104	－5.017	－2.013	－1.324
P值	?	< 0.001	0.002	< 0.001	0.044	0.186

组别	例数	NLR	SII	PLR	LMR
CMV阳性组	90	0.35 ± 0.35	107.10 ± 133.16	64.44 ± 49.47	8.20 ± 4.51
CMV阴性组	64	0.51 ± 0.50	182.40 ± 173.3	69.23 ± 29.06	6.89 ± 4.92
Z值	?	－3.388	－4.029	－0.458	－1.767
P值	?	< 0.001	< 0.001	0.647	0.077

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