Hematological and immune system damage in patients of severe fever complicated with thrombocytopenia syndrome

doi:10.3877/cma.j.issn.1674-1358.2018.06.004

Abstract

Abstract:

Sever fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease characterized by fever and thrombocytopenia. Clinical manifestations involve multiple organs and systems, among which hematological and immune system injuries are more common. For the hematological system, the amount of platelets and leukocytes decreased significantly, and the lymphocyte and neutrophils also reduced in varying degrees. Many abnormal coagulation indicators suggested that the coagulation function was also damaged. For the immune system, there were abnormal cellular immune indicators including T lymphocyte subsets, NK cells and B cells. Bone marrow biopsy revealed that myelosuppression and hemophagocytic syndrome may still exist in SFTS patients. As an emerging infectious disease, it is still controversial in the pathogenesis and early diagnosis of SFTS. Therefore, the dynamic changes of hematological and immune system of SFTS patients during the development of the disease were summarized and anayzed in this review, thus providing a way to explore the pathological mechanism of SFTS and to prevent and cure in time.

Key words: Sever fever with thrombocytopenia syndrome, Hematological system, Coagulation dysfunction, Cellular immunity, Hemophagocytic syndrome

Na Sun, Zhihai Chen. Hematological and immune system damage in patients of severe fever complicated with thrombocytopenia syndrome[J]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2018, 12(06): 538-542.

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