Research progress on non-invasive serum markers for liver fibrosis assessment in patients with chronic hepatitis B

doi:10.3877/cma.j.issn.1674-1358.2018.01.003

Abstract

Abstract:

Hepatitis B virus infection associated cirrhosis and hepatocellular carcinoma are the major causes of mortality in Chinese patients with liver diseases. Effective antiviral therapy can delay the progression of fibrosis. It is crucial to stage liver fibrosis for making therapeutic decisions. Although liver biopsy remains the gold standard for assessment of fibrosis, it is invasive and limited in application. Using reliable non-invasive serum markers to evaluate liver fibrosis could reduce the need of liver biopsy. This review focuses on non-invasive serum markers for assessment of liver fibrosis.

Key words: Chronic hepatitis B, Liver fibrosis, Non-invasive, Serum marker

Caiting Jin, Liwei Guo, Weifeng Liang. Research progress on non-invasive serum markers for liver fibrosis assessment in patients with chronic hepatitis B[J]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2018, 12(01): 11-14.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhsyhlcgrbzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1674-1358.2018.01.003

https://zhsyhlcgrbzz.cma-cmc.com.cn/EN/Y2018/V12/I01/11

References 35

[1]	Ott JJ, Stevens GA, Groeger J, et al. Global epidemiology of hepatitis B virus infection: new estimates of age-specific HBsAg seroprevalence and endemicity[J]. Vaccine,2012,30(12):2212-2219.
[2]	Ganem D, Prince AM. Hepatitis B virus infection--natural history and clinical consequences[J]. N Engl J Med,2004,350(11):1118-1129.
[3]	Liao B, Wang Z, Lin S, et al. Significant fibrosis is not rare in Chinese chronic hepatitis B patients with persistent normal ALT[J]. PLoS One,2013,8(10):e78672.
[4]	Wai CT, Greenson JK, Fontana RJ, et al. A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis C[J]. Hepatology,2003,38(2):518-526.
[5]	Sterling RK, Lissen E, Clumeck N, et al. Development of a simple noninvasive index to predict significant fibrosis in patients with HIV/HCV coinfection[J]. Hepatology,2006,43(6):1317-1325.
[6]	Xiao G, Yang J, Yan L. Comparison of diagnostic accuracy of aspartate aminotransferase to platelet ratio index and fibrosis-4 index for detecting liver fibrosis in adult patients with chronic hepatitis B virus infection: a systemic review and meta-analysis[J]. Hepatology, 2015,61(1):292-302.
[7]	Zhang Z, Wang G, Kang K, et al. The diagnostic accuracy and clinical utility of three noninvasive models for predicting liver fibrosis in patients with HBV infection[J]. PLoS One,2016,11(4):e0152757.
[8]	WHO. Guidelines for the prevention, care and treatment of persons with chronic hepatitis B infection[S]. Geneva: World Health Organization, 2015.
[9]	Kim WR, Berg T, Asselah T, et al. Evaluation of APRI and FIB-4 scoring systems for non-invasive assessment of hepatic fibrosis in chronic hepatitis B patients[J]. J Hepatol,2016,64(4):773-780.
[10]	Williams AL, Hoofnagle JH. Ratio of serum aspartate to alanine aminotransferase in chronic hepatitis. Relationship to cirrhosis[J]. Gastroenterology,1988,95(3):734-739.
[11]	McPherson S, Stewart SF, Henderson E, et al. Simple non-invasive fibrosis scoring systems can reliably exclude advanced fibrosis in patients with non-alcoholic fatty liver disease[J]. Gut,2010,59(9):1265-1269.
[12]	Eminler AT, Ayyildiz T, Irak K, et al. AST/ALT ratio is not useful in predicting the degree of fibrosis in chronic viral hepatitis patients[J]. Eur J Gastroenterol Hepatol,2015,27(12):1361-1366.
[13]	Ha HL, Shin HJ, Feitelson MA, et al. Oxidative stress and antioxidants in hepatic pathogenesis[J]. World J Gastroenterol,2010,16(48):6035- 6043.
[14]	Gutteridge JM. Caeruloplasmin: a plasma protein, enzyme, and antioxidant[J]. Ann Clin Biochem,1978,15(6):293-296.
[15]	Duygu F, Karsen H, Aksoy N, et al. Relationship of oxidative stress in hepatitis B infection activity with HBV DNA and fibrosis[J]. Ann Lab Med,2012,32(2):113-118.
[16]	Zeng DW, Dong J, Jiang JJ, et al. Ceruloplasmin, a reliable marker of fibrosis in chronic hepatitis B virus patients with normal or minimally raised alanine aminotransferase[J]. World J Gastroenterol, 2016,22(43):9586-9594.
[17]	Forns X, Ampurdanes S, Llovet JM, et al. Identification of chronic hepatitis C patients without hepatic fibrosis by a simple predictive model[J]. Hepatology,2002,36(4 Pt 1):986-992.
[18]	Ucar F, Sezer S, Ginis Z, et al. APRI, the FIB-4 score, and Forn’s index have noninvasive diagnostic value for liver fibrosis in patients with chronic hepatitis B[J]. Eur J Gastroenterol Hepatol,2013,25(9):1076-1081.
[19]	Lemoine M, Shimakawa Y, Nayagam S, et al. The gamma-glutamyl transpeptidase to platelet ratio (GPR) predicts significant liver fibrosis and cirrhosis in patients with chronic HBV infection in West Africa[J]. Gut,2016,65(8):1369-1376.
[20]	Schiavon LL, Narciso-Schiavon JL, Ferraz ML, et al. The gamma-glutamyl transpeptidase to platelet ratio (GPR) in HBV patients: just adding up?[J]. Gut,2016,65(8):1369-1376.
[21]	Toshima T, Shirabe K, Ikegami T, et al. A novel serum marker, glycosylated Wisteria floribunda agglutinin-positive Mac-2 binding protein [WFA(+)-M2BP], for assessing liver fibrosis[J]. J Gastroenterol,2015,50(1):76-84.
[22]	Nishikawa H, Hasegawa K, Ishii A, et al. A proposed predictive model for advanced fibrosis in patients with chronic hepatitis B and its validation[J]. Medicine (Baltimore),2016,95(35):e4679.
[23]	Zou X, Zhu MY, Yu DM, et al. Serum WFA+ -M2BP levels for evaluation of early stages of liver fibrosis in patients with chronic hepatitis B virus infection[J]. Liver Int,2017,37(1):35-44.
[24]	Borkham-Kamphorst E, Weiskirchen R. The PDGF system and its antagonists in liver fibrosis[J]. Cytokine Growth Factor Rev,2016,28:53-61.
[25]	Zhou J, Deng Y, Yan L, et al. Serum platelet-derived growth factor BB levels: a potential biomarker for the assessment of liver fibrosis in patients with chronic hepatitis B[J]. Int J Infect Dis,2016,49:94-99.
[26]	Liu Y, Wang Z, Kwong SQ, et al. Inhibition of PDGF, TGF-beta, and Abl signaling and reduction of liver fibrosis by the small molecule Bcr-Abl tyrosine kinase antagonist Nilotinib[J]. J Hepatol,2011,55(3):612-625.
[27]	Chen B, Ye B, Zhang J, et al. RDW to platelet ratio: a novel noninvasive index for predicting hepatic fibrosis and cirrhosis in chronic hepatitis B[J]. PLoS One,2013,8(7):e68780.
[28]	Lee HW, Kang W, Kim BK, et al. Red cell volume distribution width-to-platelet ratio in assessment of liver fibrosis in patients with chronic hepatitis B[J]. Liver Int,2016,36(1):24-30.
[29]	Salkic NN, Jovanovic P, Hauser G, et al. FibroTest/Fibrosure for significant liver fibrosis and cirrhosis in chronic hepatitis B: a meta-analysis[J]. Am J Gastroenterol,2014,109(6):796-809.
[30]	Adams LA, Bulsara M, Rossi E, et al. Hepascore: an accurate validated predictor of liver fibrosis in chronic hepatitis C infection[J]. Clin Chem,2005,51(10):1867-1873.
[31]	Leroy V, Sturm N, Faure P, et al. Prospective evaluation of FibroTest^®, FibroMeter^®, and HepaScore^® for staging liver fibrosis in chronic hepatitis B: comparison with hepatitis C[J]. J Hepatol,2014,61(1):28-34.
[32]	Wong GL, Chan HL, Choi PC, et al. Non-invasive algorithm of enhanced liver fibrosis and liver stiffness measurement with transient elastography for advanced liver fibrosis in chronic hepatitis B[J]. Aliment Pharmacol Ther,2014,39(2):197-208.
[33]	Li Y, Huang YS, Wang ZZ, et al. Systematic review with meta-analysis: the diagnostic accuracy of transient elastography for the staging of liver fibrosis in patients with chronic hepatitis B[J]. Aliment Pharmacol Ther,2016,43(4):458-469.
[34]	Macaluso FS, Maida M, Camma C, et al. Steatosis affects the performance of liver stiffness measurement for fibrosis assessment in patients with genotype 1 chronic hepatitis C[J]. J Hepatol,2014,61(3):523-529.
[35]	Shan R, Yin H, Yang W, et al. Influencing factors of transient elastography in detecting liver stiffness[J]. Exp Ther Med,2016, 12(4):2302-2306.

Please choose a citation manager

Content to export