Research progress on hepatitis B virus quasispeices of chronic hepatitis B

doi:10.3877/cma.j.issn.1674-1358.2018.01.002

Abstract

Abstract:

HBV reverse transcriptase lacks proof-reading capacity, which lead to mutation and genetic variation during replication. Consequently, HBV circulates in vivo as a viral population with a spectrum of genetically distinct but closely related variants, known as quasispecies. The quasispecies have dynamic change on immune pressure and antiviral treatment, and play an important roal on the antiviral treatment, drug resistance and outcome of chronic hepatitis B. This paper reviews about the quasispeices change on the progress of chronic hepatits B.

Key words: Chronic hepatitis B, Quasispecies, Antiviral treatment

Yulian Ren, Xiuguang Song. Research progress on hepatitis B virus quasispeices of chronic hepatitis B[J]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2018, 12(01): 7-10.

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