To investigate the changes of liver function and infection-related indicators of patients with brucellosis, and to provide the basis for the diagnosis and treatment of brucellosis.

Total of 124 patients with brucellosis were collected as observation group and 100 cases with physical examination as control group from October 2012 to August 2015. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma glutamine transferase (GGT), alkaline phosphatase (ALP), total protein (TBil) and direct bilirubin (DBil), total protein (TP), albumin (ALB), ultra-sensitive C-reactive proteins (sCRP), interleukin-6 (IL-6) and procalcitonin (PCT) were detected, respectively.

The liver function indexes of ALT, AST, GGT and ALP of the patients in observation group were (94.6 ± 48.0) U/L, (72.9 ± 31.1) U/L, (108.2 ± 53.0) U/L and (131.2 ± 56.3) U/L, respectively, significantly higher than those of the control group which were (31.1 ± 21.4) U/L, (26.5 ± 9.41) U/L, (35.2 ± 30.5) U/L and (61.9 ± 24.9) U/L, with significant differences (t = 13.2, 11.0, 12.9 and 12.3, all P < 0.01). The infection related indexes of SCRP, PCT and IL-6 of the patients in observation group were (59.8 ± 23.7) mg/L, (10.9 ± 3.77) ng/ml and (16.2 ± 12.8) pg/ml, respectively, significantly higher than those of the control group which were (3.07 ± 1.20) mg/L, (0.37 ± 0.17) ng/ml and (4.58 ± 1.97) pg/ml, with significant differences (t = 28.1, 31.0 and 9.96, all P < 0.01).

The elevated liver function indexes showed that there were impaired liver function in patients with brucellosis, and the nonspecific inflammation related markers of patients with brucellosis were significantly increased.