Sialic acid-binding immunoglobulin-like lectins-9: a novel regulator of neutrophil apoptosis

doi:10.3877/cma.j.issn.1674-1358.2017.02.002

Abstract

Abstract:

Sialic acid-binding immunoglobulin-like lectins (Siglecs) are members of the major superfamily of immune receptors differentially which presented on the surface of hematopoietic cells and recognized sialic acid. Neutrophils are recognized as one of the key effector cells of the innate immune system during the development of the early inflammatory responses. Apoposis plays a key role in the regulation of the number of neutrophils. This paper reviews the role of Siglec-9 in the regulation of neutrophil recruitment, apoptosis, inflammatory responses, autophagy and recent progress of Siglec-9 in clinical diseases.

Key words: Sialic acid-binding immunoglobulin-like lectins-9, Neutrophil, Apoptosis, Inflammation

Sasa Chu, jin Zhu, Maorong Wang. Sialic acid-binding immunoglobulin-like lectins-9: a novel regulator of neutrophil apoptosis[J]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2017, 11(02): 111-116.

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