Progress of intestinal mucosal barrier dysfunction in severe acute pancreatitis

doi:10.3877/cma.j.issn.1674-1358.2016.06.003

Abstract

Abstract:

Severe acute pancreatitis (SAP) is a severe disease, with many complications and high fatality rate. In the past few decades, the incidence rate of SAP increased significantly, which could damage the intestinal mucosa barrier, lead to bacterial and endotoxin translocation, pancreatic tissue infection, and then systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome, eventually affects the prognosis of the patients. During SAP, intestinal mucosa barrier damage plays a key role. Therefore, the research of intestinal mucosal barrier dysfunction mechanism in SAP is important. The progress of intestinal mucosal barrier dysfunction in SAP were reviewed.

Key words: Severe acute pancreatitis (SAP), Intestinal mucosa barrier, Inflammation medium

Hui Chen, Tao Lan. Progress of intestinal mucosal barrier dysfunction in severe acute pancreatitis[J]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2016, 10(06): 659-662.

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