To investigate drug resistance and clinical distribution of Klebsiella pneumoniae collected from different wards in our hospital, thus to guide rational clinical application of antibacterial.

Klebsiella pneumonia were separated from pediatric ward, intensive care unit and neurosurgical unit from January 2014 to December 2014 in our hospital, the drug resistance to 19 antibacterial and clinical distribution were analyzed, retrospectively by WHONET 5.6.

The drug resistance rates of Klebsiella pneumoniae collected from these three wards were 147 stains, 72 strains and 73 strains , the rates of drug resistance to levofloxacin, amoxicillin/clavulanic acid, cefoxitin, piperacillin/tazobactam, amikacin, imipenem, meropenem and ertapenem were all less than 30%; the drug resistance rates to cefazolin, cefuroxime, cefotaxime, cefepime, ceftazidime, aztreonam and cotrimoxazole varied were 35.6%-71.2%; the drug resistance rates to gentamicin and tobramycin varied were 12.2%-50.0%; the drug resistance rates to ciprofloxacin varied from 6.1%-36.1%. There were 52 strains (72.2%), 132 strains (89.9%) and 70 strains (95.9%) collected from sputum in ICU, pediatric ward and neurosurgical unit, respectively.

Klebsiella pneumoniae collected from different wards in our hospital mainly caused respiratory tract infection. The drug resistance rates of these strains to cephalosporins were relatively high, which varied widely to fluoroquinolone antibiotics, so the antibiotics treatment should be selected according to drug test.