To investigate the effect of comprehensive nursing care on the healing of ulcer in children with hand, foot and mouth disease (HFMD) and the nursing satisfaction rates.

Total of 180 children with HFMD and oral ulcer treated in our hospital from January 2014 to January 2015, were collected and divided into observation group and control group, each with 90 cases, respectively. The patients in control group received routine nursing care, while thoes in observation group received the comprehensive nursing on skin care, diet, oral mucous and other aspects based on routine nursing. Meanwhile, the treatment of children with oral ulcer and nursing satisfaction rates of the two groups were compared, respectively.

The disease duration of observation group was significantly shorter than that of the control group, with significant difference (t = 2.264, P = 0.002). The patients’ oral ulcer were healed after the treatment in both groups, and the durations of oral ulcer pain relief time and healing time of oral ulcer of the children in the observation group were significantly shorter than those of the control group (χ²= 4.585, P = 0.000; χ²= 3.723, P = 0.000). The nursing satisfaction rates were 97.78% and 85.56% of families of the children in the observation group and the control group, respectively, with significant difference (χ²= 8.800, P = 0.003).

Compared with the conventional care, the comprehensive nursing intervention could shorten the durations of oral ulcer pain relief time and healing time, and shorten the disease duration time of the cases with HFMD, so as to improve the nursing satisfaction.