To analyze the annual reporting to China Antimicroblal Resistance Survellance System data of our hospital in 2014, and to understand the distribution of hospital clinical isolates, specimen source, the distribution of drug resistance and multi-drug resistant pathogens.

Clinical isolates of pathogens distribution, specimen source, the distribution of multi-drug resistant and drug sensitivity test from software for January 2014 to December 2014 in our hospital were analyzed by WHONET 5.6 software, retrospectively.

Among all the 4 779 isolated, Gram-negative bacteria accounted for 79.92% (3 819/4 779), and Gram-positive bacteria accounted for 20.08% (960/4 779). The top five bacteria were Escherichia coli (1 477 strains, accounting for 30.91%), Klebsiella pneumoniae (677 strains, accounting for 14.17%), Pseudomonas aeruginosa (430 strains, accounting for 9% ), Acinetobacter (290 strains, accounting for 6.07%) and Enterococcus faecalis (270 strains, accounting for 5.65%). The top five clinical isolates of the department were pediatric (801 strains, accounting for 16.76%), general surgery (447 strains, accounting for 9.35%), urology (424 strains, accounting for 8.87%), respiratory medicine (341 strains, accounting for 7.14%) and critical care medicine (335 strains, accounting for 7.01%). The top five types specimens were respiratory specimens (1 824 strains, accounting for 38.17%), urine (1 050 strains, accounting for 21.97%), secretions (523 strains, accounting for 10.94%), drainage (513 strains, accounting for 10.73%) and blood (361 strains, accounting for 7.55%). Methicillin-resistant coagulase-negative Staphylococci (53/148, 35.81%), producing extended spectrum β-lactamases (788/2 221, 35.48%), resistance to carbapenems Bowman Acinetobacter (9/52, 17.31%), methicillin-resistant Staphylococcus aureus (29/205, 14.15%), Enterobacteriaceae resistant to carbapenem 15 (15/2 712, 0.55%) were isolated, while penicillin-resistant Streptococcus pneumoniae unseparated to vancomycin-resistant Enterococci(VRE) and penicillin resistant Streptococcus pneumonia (PRSP) were not found.

The 2014 annual drug monitoring data analysis, on the distribution of hospital clinical isolates, specimen source, multi-drug-resistant and drug-resistant bacteria could guide clinical rational use of antibiotics in clinical to improve the security.