To analyze the method and clinical effect of 6 h bundle of anti-infective therapy in patients with septic shock in emergency department, retrospectively.

Total of 173 cases of infection shock with cluster of anti-infective therapy from January 2013 to December 2014 in emergency department of our hospital were analyzed, retrospectively and were set as the research objects, the effects of general data of patients, mortality rate and the related factors, cluster treatment method, cluster treatment implementation rate and complete bundle treatment on mortality were analyzed, respectively.

Age above 60 years old, APACHE II score higher than 20, systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS) occurred in patients with septic shock and mortality were all independent risk factors. The implementation rates were higher of blood lactate detection, broad-spectrum antibacterial drug application in 3 h, fluid resuscitation effect was poor and given boost therapy. But there was still a significant rise in non-complete bundle therapy. the implementation rate of pathogenic bacteria was low before the treatment, and the fatality rate of cases with complete bundle therapy was lower than that of complete bundle therapy (χ² = 6.564, P = 0.0104).

Septic shock patients were treated by anti-infection treatment within 6 h in emergency, which could effectively achieve the goal of treatment index control, and improve the implementation rate of complete bundle of emergency physician, then furtherly reduce the mortality rate of patients with septic shock.