To explore the main kinds of liver diseases which threat human health in recent years and also discuss clinical epidemiology and features of HBV associated with primary carcinoma of the liver, conducted to find reliable evidence-based medicine values.

The demographic characteristics and clinical features of hospitalized patients with liver disease from January 2005 to December 2013 in our hospital were collected, whose first diagnosis were hepatopathy with complete demographic and clinical data. The spectrum changes of liver diseases, the clinical feature and anti-virus therapy for patients with HBV related primary carcinoma of the liver were analyzed prospectively by SPSS 16.0 software.

During the 9 years, patients with viral related liver diseases, especially HBV associated liver diseases occupied the majority constituent ratio in all hospitalized patients with liver diseases. The ratio of patients with HBV related primary carcinoma of the liver was on the rise. Most of them did not receive anti-viral therapy before the primary carcinoma of the liver diagnosed, or with cancer transfer to far place as the primary carcinoma of the liver was diagnosed. After antiviral treament, patients of primary carcinoma of the liver had better prognosis.

In recent years, among inpatients, the ratio of HBV associated liver diseases, especially primary carcinoma of the liver, presented an upward trend. The ones who received anti-virus treatment could get better prognosis.