Correlation of upper gastrointestinal symptoms between Helicobacter pylori infection and gastric precancerous disease

doi:10.3877/cma.j.issn.1674-1358.2016.03.014

Abstract

Abstract:

Objective

To explore the correlation of gastrointestinal symptoms, Helicobacter pylori (HP) infection and gastric precancerous diseases.

Methods

Patients diagnosed as chronic gastritis were selected from January 2013 to October 2014. Then the patients were divided into upper gastrointestinal symptoms of positive group (360 cases) and negative group (360 cases). All patients were tested by 14C breath test and diagnosised with biopsy in endoscopy. The relationship between the upper gastrointestinal symptoms in patients with HP positive rate and the upper gastrointestinal symptoms with endoscopy biopsy diagnosis of precancerous disease were compared, respectively.

Results

The HP detection rate of upper gastrointestinal symptoms positive group was significantly higher than that of negative group (χ² = 353.892, P = 0.000). The incidence of chronic gastritis with symptoms of upper gastrointestinal dysplasia positive group was significantly higher than that of negative group (χ² = 12.328, P = 0.000).

Conclusions

Upper gastrointestinal symptoms was correlated with HP infection, and there were relevantion between upper gastrointestinal symptoms and chronic gastritis.

Key words: Helicobacter pylori, Upper gastrointestinal symptoms, Precancerous diseases, Correlation

Qiong Xie, Yueyue Lu, Hongfeng Yi. Correlation of upper gastrointestinal symptoms between Helicobacter pylori infection and gastric precancerous disease[J]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2016, 10(03): 319-322.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhsyhlcgrbzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1674-1358.2016.03.014

https://zhsyhlcgrbzz.cma-cmc.com.cn/EN/Y2016/V10/I03/319

Figures/Tables 1

References 25

1	Adamczyk M, PeczekŁ, Rudnicki C, et al. The clinical significance of gastropanel in diagnostics of Helicobacter pylori eradication efficiency in patients with dyspepsia with correlation of family history of gastric cancer[J]. Pol Merkur Lekarski,2013,35(207):141-147.
2	刘文忠，萧树东. 幽门螺杆菌新国际共识解读[J]. 胃肠病学,2012,17(1):1-4.
3	Suzuki H, Nishizawa T, Hibi T. Can Helicobacter pylori-associated dyspepsia be categorized as functional dyspepsia?[J]. J Gastroenterol Hepatol,2011,26(3):42-45.
4	Jafarzadeh A, Nemati M, Rezayati MT, et al. Higher circulating levels of anti-phosphatidylserine antibody in peptic ulcer patients infected with CagA-positive strains of Helicobacter pylori[J]. Clin Lab,2013,59(9-10):977-984.
5	Liu J, He C, Chen M, et al. Association of presence/absence and on/off patterns of Helicobacter pylori oipA gene with peptic ulcer disease and gastric cancer risks:a meta-analysis[J]. BMC Infect Dis,2013,13:555.
6	黄叶妮，刘丽. 幽门螺杆菌感染的治疗进展[J]. 现代生物医学进展,2012,12(17):3398-3399.
7	成积儒，蔡永林，黄德旺, 等. 336例上消化道疾病患者的幽门螺杆菌抗体谱检测结果分析[J]. 广西医学,2009,31(6):807-808.
8	Futagami S, Shimpuku M, Yin Y, et al. Pathophysiology of functional dyspepsia[J]. J Nihon Med Sch,2011,78(5):280-285.
9	Lansdorp-Vogelaar I, Sharp L. Cost-effectiveness of screening and treating Helicobacter pylori for gastric cancer prevention[J]. Best Pract Res Clin Gastroenterol,2013,27(6):933-947.
10	Miwa H, Watari J, Fukui H, et al. Current understanding of pathogenesis of functional dyspepsia[J]. J Gastroenterol Hepatol,2011,26(3):53-60.
11	Suzuki H, Matsuzaki J, Hibi T. What is the difference between Helicobacter pylori-associated dyspepsia and functional dyspepsia?[J]. J Neurogastroenterol Motil,2011,17(2):124-130.
12	Saito Y, Suzuki H, Tsugawa H, et al. Dysfunctional gastric emptying with down-regulation of muscle-specific microRNAs in Helicobacter pylori-infected mice[J]. Gastroenterology,2011,140(1):189-198.
13	Takeuchi K, Ohishi M, Ota S, et al. Metabolic profiling to identify potential serum biomarkers for gastric ulceration induced by nonsteroid anti-inflammatory drugs[J]. J Proteome Res,2013,12(3):1399-1407.
14	于中麟. 慢性胃炎的内镜分型分级标准及治疗的试行意见[J]. 中华消化内镜杂志,2004,21(2):4-5.
15	Kato M, Ono S, Yoshida T, et al. Significance of H. pylori eradication in treatment and prevention for low-dose aspirin induced gastric ulcer of elderly[J]. NihonRinsho,2010,68(11):2089-2095.
16	Naqano Y, Matsui H, Tamura M, et al. NSAIDs and acidic environment induce gastric mucosal cellular mitochondrial dysfunction[J]. Digestion,2012,85(2):131-135.
17	朱玉群，杨绍徐. 幽门螺旋菌感染与胃癌的相关性研究[J]. 首都医科大学学报,2009,3(17):49-50.
18	Boike JR, Kao R, Meyer D, et al. Does concomitant use of paracetamol potentiate the gastroduodenal mucosal injury associated with aspirin? A prospective, randomised, pilot study[J]. Aliment Pharmacol Ther,2012,36(4):391-397.
19	朱敏，袁昌琼，杨慧英, 等. 胃肠外疾病患者幽门螺旋杆菌感染治疗探析[J]. 河北医学,2013,19(12):1795-1797.
20	Seo PJ, Kim N, Kim JH, et al. Comparison of indomethacin, diclofenac and aspirin-induced gastric damage according to age in rats[J]. Gut Liver,2012,6(2):210-217.
21	Tamural I, Fujita T, Tsumura H, et al. Low-dose aspirin-induced gastroduodenal mucosal injury in Japanese patients with arteriosclerotic disease[J]. Inter Med,2010,49(23):2537-2545.
22	Ryter SW, Cloonan SM, Choi AM. Autophagy: a critical regulator of cellular metabolism and homeostasis[J]. Mol Cells,2013,36(1):7-16.
23	Chen HC, Fong TH, Lee AW, et al. Autophagy is activated in injured neurons and inhibited by methylprednisolone after experimental spinal cord injury[J]. J Spine,2012,37:470-475.
24	He LQ, Lu JH, Yue ZY. Autophagy in ageing and ageing-associated diseases[J]. Acta Pharmacol Sin,2013,34(5):605-611.
25	Naqano Y, Matsui H, Tamura M, et al. NSAIDs and acidic environment induce gastric mucosal cellular mitochondrial dysfunction[J]. Digestion,2012,85(2):131-135.

上消化道症状	慢性萎缩性胃炎	胃上皮不典型增生	肠上皮化生
阳性	28（7.8）	46（12.8）	49（13.6）
阴性	22（6.1）	19（5.3）	46（12.8）
χ²值	0.774	12.328	0.109
P值	0.379	0.000	0.741

上消化道症状	慢性萎缩性胃炎	胃上皮不典型增生	肠上皮化生
阳性	28（7.8）	46（12.8）	49（13.6）
阴性	22（6.1）	19（5.3）	46（12.8）
χ²值	0.774	12.328	0.109
P值	0.379	0.000	0.741

[1]	Shuihua Yang, Guidan He, Guican Qin, Mengfeng Liang, Yanhe Luo, Xueqin Li, Juansong Tang. Echocardioimagedata characteristics of fetal isolated total anomalous pulmonary venous connection and application of high definition flow imaging and spatio-temporal image correlation [J]. Chinese Journal of Medical Ultrasound (Electronic Edition), 2023, 20(10): 1061-1067.
[2]	Hua Yuan, Bowen Zhao, Zuoping Xie, Qiqi Hua, Jiamei Zhou, Heqing Guo, Yan Chen, Mei Pan. Comparative study of electronic spatio-temporal image correlation technique and spatio-temporal image correlation technique in displaying fetal heart diagnostic views [J]. Chinese Journal of Medical Ultrasound (Electronic Edition), 2022, 19(09): 926-932.
[3]	Mengsheng Li, Zhongbo Han. High risk and controllable factor of gastric cancer--Helicobacter pylori infection [J]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2023, 17(03): 145-150.
[4]	Zhanbin Cui, Junli Qiao, Lili Zhang, Mingqiang Han. Correlation between urinary iodine levels and stratified risk of recurrence in patients with papillary thyroid cancer after surgery [J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2023, 17(06): 615-618.
[5]	Xiaohui Li, Changsheng Shangguan, Ying Xiang, Zhijie Pei, Junzhi Che, Fei Xie. Relationship between body energy metabolism and sex hormone levels in patients with polycystic ovary syndrome after 3D laparoscopic sleeve gastrectomy [J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2023, 17(05): 538-541.
[6]	Chunjiang Pan, Ke Li, Xinlou Li, Bo Yang, Xueling Ren. Relationship between markers of bone turnover metabolism and renal function in the elderly people [J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2023, 12(05): 260-264.
[7]	Yuyan Zhang, Bin Hu, Weihong Zhang, Mei Xu, Hui Zhu, Xinyue Yang, Hailing Liu. Relationship between echocardiography parameters and liver function during the second trimester of pregnancy and their predictive value for adverse pregnancy outcomes [J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2023, 13(06): 499-504.
[8]	Xiaoqiong Shi, Guojian Yin. Study on diagnostic accuracy of Helicobacter pylori rapid urease test with different observation time [J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2023, 13(03): 150-154.
[9]	Hongtao Wei, Cangjue Pubu, Yangzong Gesang, Yan Li, Wangza Yixi, Peng Li. Helicobacter pylori infection in patients with upper gastrointestinal ulcer in Lhasa: clinical presentation, prognosis, and treatment outcomes [J]. Chinese Journal of Clinicians(Electronic Edition), 2023, 17(06): 662-665.
[10]	Jie Chen, Yi Bai, Jinbo Liu, Huan Liu, Na Zhao, Hongwei Zhao, Hongyu Wang. Correlation between neutrophil/high-density lipoprotein ratio and lower extremity arterial disease in middle-aged and elderly people [J]. Chinese Journal of Clinicians(Electronic Edition), 2023, 17(04): 402-408.
[11]	Shuyi Zeng, Xiangwen Liang, Zhihai Lin, Yiyi Li, Zheng Ling, Zhengdong Wang. Relationship of 24-hour urinary protein and blood pressure variability with sleep disorders in patients with essential hypertension [J]. Chinese Journal of Clinicians(Electronic Edition), 2023, 17(01): 48-53.
[12]	Lichao Gao, Qiang Lv, Yujie Wang, Dongmei Zhang, Wenfei Ding, Ling Cao, Santao Ou. Combined determination of peripheral blood miRNA-21 and miRNA-192 for prediction of early renal function impairment in chronic glomerulonephritis [J]. Chinese Journal of Clinicians(Electronic Edition), 2022, 16(09): 887-891.
[13]	Jiaguang Su, Jiacan Huang, Yanbin Pan, Wenjun Zheng. Correlation between chemokine and skin lesions, obesity, glucose lipid metabolism and inflammatory factors in patients with psoriasis [J]. Chinese Journal of Clinicians(Electronic Edition), 2022, 16(06): 513-518.
[14]	Ruifu Yang, Yanbin Zhou. Research progress on the correlation of major facilitator superfamily membrane transporters and bacterial biofilm formation [J]. Chinese Journal of Diagnostics(Electronic Edition), 2023, 11(02): 77-81.
[15]	Xiaobei Zhang, Weigang Wang, Xiaolong Li, Fengjun Yi, Yongjiang Yu. Correlation of H. pylori infection and different subtypes of gastroesophageal reflux disease [J]. Chinese Journal of Gastroesophageal Reflux Disease(Electronic Edition), 2023, 10(01): 1-5.

Please choose a citation manager

Content to export