Clinical analysis of Gram-positive cocci infection with linezolid after operation

doi:10.3877/cma.j.issn.1674-1358.2016.03.008

Abstract

Abstract:

Objective

To analyze the clinical effect and safety of linezolid treatment after orthopedics operation of Gram-positive cocci infection.

Methods

The clinical data of 23 patients with Gram-positive cocci infection with linezolid treatment after surgery in the department of orthopedics in two hospitals from January 2010 to June 2014 were analyzed, retrospectively.

Results

All patients were detected for Gram-positive cocci infection, among which, 11 cases of infection after lumbar operation, 7 cases of limb bone fracture internal fixation postoperative infection, 5 cases of postoperative infection around the hip joint prosthesis. The total effective rate was 95.7% and the effective time was 3-10 days. There were 14 cases of direct use of linezolid, which of effective in 13 (92.9%) cases, while 9 cases of vancomycin resistant or intolerant were change to linezolid, which of effective in 7 (77.8%) cases. A total of 5 cases were with adverse reactions, 2 cases with diarrhea, 2 cases with skin rash, 1 cases with leukopenia and thrombocytopenia. All patients were able to tolerate and the symptoms disappeared after withdrawal.

Conclusions

The treatment of the department of orthopedics after operation of Gram-positive cocci infection with linezolid is safe and effective. It could be applied to anti-Gram-positive bacterial infections treatment or ineffective treatment for vancomycin.

Key words: Linezolid, Gram-positive cocci, Infection, Orthopedics, Clinical analysis

Feng Chen, Hongyan Gao, Tianyang Zhang, Yu Teng, Lin Jiang, Weiguo Zhang, Zhi Guo. Clinical analysis of Gram-positive cocci infection with linezolid after operation[J]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2016, 10(03): 290-293.

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References 25

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项目		株数	例（%）
年龄
	> 60岁	6	15（65.2）
	≤ 60岁	4	8（34.8）
症状
	发热		19（82.6）
	切口肿胀		20（87.0）
	局部疼痛		18（78.3）
	伤口渗液		15（65.2）
	利奈唑胺使用方法
	直接使用		14（60.9）
	万古霉素无效后替换使用		9（39.1）

项目		株数	例（%）
年龄
	> 60岁	6	15（65.2）
	≤ 60岁	4	8（34.8）
症状
	发热		19（82.6）
	切口肿胀		20（87.0）
	局部疼痛		18（78.3）
	伤口渗液		15（65.2）
	利奈唑胺使用方法
	直接使用		14（60.9）
	万古霉素无效后替换使用		9（39.1）

病原菌	株数	构成比（%）
金黄色葡萄球菌	10	43.5
表皮葡萄球菌	6	26.1
凝固酶阴性葡萄球菌	4	17.4
链球菌	2	8.7
屎肠球菌	1	4.3
合计		100.0

病原菌	株数	构成比（%）
金黄色葡萄球菌	10	43.5
表皮葡萄球菌	6	26.1
凝固酶阴性葡萄球菌	4	17.4
链球菌	2	8.7
屎肠球菌	1	4.3
合计		100.0

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