The glucolipid metabolism characteristics of newly diagnosed male patients with acquired immune deficiency syndrome

doi:10.3877/cma.j.issn.1674-1358.2016.03.006

Abstract

Abstract:

Objective

To investigate the glucolipid metabolism characteristics of newly diagnosed acquired immune deficiency syndrome (AIDS) male patients before highly actively antiretroviral therapy (HAART).

Methods

The glucolipid metabolism parameters including BMI, glucose, blood lipid, blood pressure, uric acid, HOMA-IR and HOMA-β between newly diagnosed male patients with AIDS before HAART (disease group) and synchronous healthy male (control group) were tested and analyzed, respectively.

Results

Compared with control group, patients in disease group had higher levels of fasting glucose (5.54 mmol/Lvs 4.97 mmol/L; t = 4.980, P = 0.000) and lower level of BMI and total cholesterol, accompanied with more lower level of HOMA-β (20.46% vs 99.48%; t = 5.011, P = 0.000). Pearson analysis showed that HIV virus load was negatively correlated with HOMA-IR (r =-0.474, P = 0.03) and HOMA-β (r =-0.368, P = 0.077).

Conclusions

Newly diagnosed male patients with AIDS frequently have higher fasting glucose and hypofunction of pancreas islet β cells, which have certain relationship with HIV virus load. The monitor of glucose regularly should be paied attention and be vigilant on diabetes.

Key words: Acquired immune deficiency syndrome (AIDS), Newly diagnosed, Male, Glucolipid metabolism, Highly active antiretroviral therapy (HAART)

Lijuan Lan, Dafeng Liu, Zhu Chen, Shenghua He, Yaling Liu, Yong Wang, Yi Xin. The glucolipid metabolism characteristics of newly diagnosed male patients with acquired immune deficiency syndrome[J]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2016, 10(03): 280-284.

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References 28

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组别	例数	年龄（岁）	身高（cm）	体重（kg）	BMI（kg/m²）	SBP（mmHg）
病例组	50	32.40 ± 9.08	170.62 ± 5.39	62.30 ± 10.44	21.33 ± 2.80	111.20 ± 8.62
对照组	50	33.16 ± 4.62	164.14 ± 7.91	64.51 ± 14.96	23.89 ± 4.91	119.13 ± 11.90
t值		24.000	6.450	6.770	17.360	2.640
P值		0.599	0.000	0.427	0.005	0.000
组别	例数	DBB（mmHg）	FPG（mmol/L）	UA（mmol/L）	TC（mmol/L）	TG（mmol/L）
病例组	50	73.14 ± 5.47	5.54 ± 0.51	359.49 ± 86.33	4.11 ± 0.74	1.85 ± 2.42
对照组	50	75.39 ± 8.45	4.97 ± 0.70	326.02 ± 135.55	4.52 ± 1.01	1.87 ± 1.58
t值		8.560	4.980	8.440	4.775	0.290
P值		0.133	0.000	0.148	0.031	0.953
组别	例数	HDL-L（mmol/L）	LDL-L（mmol/L）	FINS（µIU/L）	HOMA-IR	HOMA-β（%）
病例组	50	1.08 ± 0.23	2.62 ± 0.61	5.144 ± 5.67	1.30 ± 0.53	20.46 ± 6.17
对照组	50	1.09 ± 0.47	2.69 ± 1.00	9.12 ± 10.95	2.27 ± 0.51	92.48 ± 2.47
t值		10.200	6.480	1.964	2.967	5.011
P值		0.928	0.690	0.053	0.004	0.000

组别	例数	年龄（岁）	身高（cm）	体重（kg）	BMI（kg/m²）	SBP（mmHg）
病例组	50	32.40 ± 9.08	170.62 ± 5.39	62.30 ± 10.44	21.33 ± 2.80	111.20 ± 8.62
对照组	50	33.16 ± 4.62	164.14 ± 7.91	64.51 ± 14.96	23.89 ± 4.91	119.13 ± 11.90
t值		24.000	6.450	6.770	17.360	2.640
P值		0.599	0.000	0.427	0.005	0.000
组别	例数	DBB（mmHg）	FPG（mmol/L）	UA（mmol/L）	TC（mmol/L）	TG（mmol/L）
病例组	50	73.14 ± 5.47	5.54 ± 0.51	359.49 ± 86.33	4.11 ± 0.74	1.85 ± 2.42
对照组	50	75.39 ± 8.45	4.97 ± 0.70	326.02 ± 135.55	4.52 ± 1.01	1.87 ± 1.58
t值		8.560	4.980	8.440	4.775	0.290
P值		0.133	0.000	0.148	0.031	0.953
组别	例数	HDL-L（mmol/L）	LDL-L（mmol/L）	FINS（µIU/L）	HOMA-IR	HOMA-β（%）
病例组	50	1.08 ± 0.23	2.62 ± 0.61	5.144 ± 5.67	1.30 ± 0.53	20.46 ± 6.17
对照组	50	1.09 ± 0.47	2.69 ± 1.00	9.12 ± 10.95	2.27 ± 0.51	92.48 ± 2.47
t值		10.200	6.480	1.964	2.967	5.011
P值		0.928	0.690	0.053	0.004	0.000

组别	例数	BMI（Kg/m²）	SBP（mmHg）	DBP（mmHg）	FPG（mmol/L）	UA（µmol/L）	TC（mmol/L）
A组	26	20.14 ± 1.81	109.83 ± 7.63	71.33 ± 5.66	5.68 ± 0.41	329.08 ± 78.93	4.00 ± 0.85
B组	10	22.03 ± 2.72	110.22 ± 8.12	73.57 ± 4.59	5.58 ± 0.52	352.61 ± 77.45	4.12 ± 0.73
C组	14	21.43 ± 3.50	115.00 ± 9.19	74.93 ± 5.55	5.36 ± 0.56	398.44 ± 97.59	4.19 ± 0.71
F值		1.160	2.651	3.141	2.690	4.525	0.446
P值		0.288	0.110	0.083	0.108	0.039	0.508
组别	例数	TG（mmol/L）	HDL-c（mmol/L）	LDL-c（mmol/L）	HOMA-IR	HOMA-β（%）
A组	26	2.35 ± 1.57	0.99 ± 0.24	2.30 ± 0.67	1.42 ± 0.79	40.92 ± 2.03
B组	10	1.66 ± 1.05	1.09 ± 0.23	2.79 ± 0.45	1.31 ± 0.54	19.94 ± 6.98
C组	14	1.73 ± 1.36	1.13 ± 0.23	2.62 ± 0.72	1.21 ± 1.00	13.19 ± 8.23
F值		0.375	2.303	1.629	0.037	0.038
P值		0.543	0.136	0.208	0.964	0.963

组别	例数	BMI（Kg/m²）	SBP（mmHg）	DBP（mmHg）	FPG（mmol/L）	UA（µmol/L）	TC（mmol/L）
A组	26	20.14 ± 1.81	109.83 ± 7.63	71.33 ± 5.66	5.68 ± 0.41	329.08 ± 78.93	4.00 ± 0.85
B组	10	22.03 ± 2.72	110.22 ± 8.12	73.57 ± 4.59	5.58 ± 0.52	352.61 ± 77.45	4.12 ± 0.73
C组	14	21.43 ± 3.50	115.00 ± 9.19	74.93 ± 5.55	5.36 ± 0.56	398.44 ± 97.59	4.19 ± 0.71
F值		1.160	2.651	3.141	2.690	4.525	0.446
P值		0.288	0.110	0.083	0.108	0.039	0.508
组别	例数	TG（mmol/L）	HDL-c（mmol/L）	LDL-c（mmol/L）	HOMA-IR	HOMA-β（%）
A组	26	2.35 ± 1.57	0.99 ± 0.24	2.30 ± 0.67	1.42 ± 0.79	40.92 ± 2.03
B组	10	1.66 ± 1.05	1.09 ± 0.23	2.79 ± 0.45	1.31 ± 0.54	19.94 ± 6.98
C组	14	1.73 ± 1.36	1.13 ± 0.23	2.62 ± 0.72	1.21 ± 1.00	13.19 ± 8.23
F值		0.375	2.303	1.629	0.037	0.038
P值		0.543	0.136	0.208	0.964	0.963

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