To investigate the distribution, drug resistance and the risk factors of postoperative fungal infections in patients with gastric cancer, and to provide better clinical strategy in prevention and treatment.

The operation data and postoperative specimens of 256 patients with gastric cancer were analyzed, retrospectively, from January 2013 to December 2014 in Affiliated Hospital of the Armed Police Logistics College. The distribution and drug resistance of postoperative fungal infections were examined respectively. The univariate and multivariate logistic regression analysis were adopted to discuss the risk factors of postoperative fungal infections.

The postoperative fungal infections occurred in 103 among the 256 cases with gastric cancer, with the infection rate of 40.23%. Total of 139 strains of pathogenic bacteria were isolated, Candida albicans were isolated the most frequently, accounting for 66.91%. Anti-fungal susceptibility test showed that fungi were highly sensitive to amphotericin B and 5-fluorocytosine, but lower to triazole antifungal. Age, preoperative smoking history, tumor node metastasis (TNM) staging of gastric cancer patients, antimicrobial drugs before surgery, intraoperative use of electric knife, postoperative length of stay and postoperative bacterial infection were the risk factors for fungal infections after surgery. Multivariate logistic regression analysis showed that the patients with 60 years old or older, preoperative history of smoking, TNM stage at Ⅲ-Ⅳ stage, intraoperative use of electric knife and postoperative bacterial infection were independent risk factors for fungal infections after surgery (P all < 0.05).

The incidence of postoperative fungal infections in patients with gastric cancer was highly relative with multiple risk factors. It is necessary to take effective preventive measures and select active antifungal drug for the patients with infections in clinical treatment.