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中华实验和临床感染病杂志(电子版) ›› 2018, Vol. 12 ›› Issue (06) : 538 -542. doi: 10.3877/cma.j.issn.1674-1358.2018.06.004

所属专题： 文献；

综述

发热伴血小板减少综合征患者的血液及免疫系统损伤
孙娜1, 陈志海2,†()   
  1. 1. 100015　北京；首都医科大学附属北京地坛医院药学部
    2. 100015　北京；首都医科大学附属北京地坛医院感染中心
  • 收稿日期:2018-04-25 出版日期:2018-12-15
  • 通信作者: 陈志海
  • 基金资助:
    北京市医院管理局临床医学发展专项(No. XMLX201502；ZYLX201602)

Hematological and immune system damage in patients of severe fever complicated with thrombocytopenia syndrome

Na Sun1, Zhihai Chen2,†()   

  1. 1. Pharmacy Department,, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China
    2. Clinical and Research Center of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China
  • Received:2018-04-25 Published:2018-12-15
  • Corresponding author: Zhihai Chen
  • About author:
    Corresponding author: Chen Zhihai, Email:
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孙娜, 陈志海. 发热伴血小板减少综合征患者的血液及免疫系统损伤[J]. 中华实验和临床感染病杂志(电子版), 2018, 12(06): 538-542.

Na Sun, Zhihai Chen. Hematological and immune system damage in patients of severe fever complicated with thrombocytopenia syndrome[J]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2018, 12(06): 538-542.

发热伴血小板减少综合征（SFTS）是以发热伴血小板减少为主要特征的新发传染病。临床表现常累及多个器官，其中以血液和免疫系统损伤较为常见。血液系统方面，患者血小板及白细胞数量明显减少，淋巴细胞及中性粒细胞等也出现不同程度减少，多项凝血指标异常提示凝血功能存在损伤；免疫系统方面，T淋巴细胞亚群、NK细胞及B细胞等多项细胞免疫指标异常，同时骨髓穿刺发现SFTS患者可能存在骨髓抑制及噬血细胞综合征。作为新发传染病，SFTS发病机制和早期诊断等尚存在争议，本文对SFTS患者血液和免疫系统在该疾病发展过程中的动态变化特点进行综述，为探讨SFTS病理机制和及时防治提供思路。

关键词: 发热伴血小板减少综合征, 血液系统, 凝血障碍, 细胞免疫, 噬血细胞综合征

Sever fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease characterized by fever and thrombocytopenia. Clinical manifestations involve multiple organs and systems, among which hematological and immune system injuries are more common. For the hematological system, the amount of platelets and leukocytes decreased significantly, and the lymphocyte and neutrophils also reduced in varying degrees. Many abnormal coagulation indicators suggested that the coagulation function was also damaged. For the immune system, there were abnormal cellular immune indicators including T lymphocyte subsets, NK cells and B cells. Bone marrow biopsy revealed that myelosuppression and hemophagocytic syndrome may still exist in SFTS patients. As an emerging infectious disease, it is still controversial in the pathogenesis and early diagnosis of SFTS. Therefore, the dynamic changes of hematological and immune system of SFTS patients during the development of the disease were summarized and anayzed in this review, thus providing a way to explore the pathological mechanism of SFTS and to prevent and cure in time.

Key words: Sever fever with thrombocytopenia syndrome, Hematological system, Coagulation dysfunction, Cellular immunity, Hemophagocytic syndrome
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