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中华实验和临床感染病杂志(电子版) ›› 2018, Vol. 12 ›› Issue (06) : 543 -546. doi: 10.3877/cma.j.issn.1674-1358.2018.06.005

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综述

侵袭性肺部曲霉菌病生物标志物研究进展
张军昌1, 许彪1, 王永刚1,()   
  1. 1. 100039 北京,中国人民解放军总医院第五医学中心重症医学中心
  • 收稿日期:2018-05-04 出版日期:2018-12-15
  • 通信作者: 王永刚

Advances on biomarkers for invasive pulmonary aspergillosis

Junchang Zhang1, Biao Xu1, Yonggang Wang1,()   

  1. 1. Critical Care Center, the Fifth Medical Center of the PLA General Hospital, Beijing 100039, China
  • Received:2018-05-04 Published:2018-12-15
  • Corresponding author: Yonggang Wang
  • About author:
    Corresponding author: Wang Yonggang, Email:
引用本文:

张军昌, 许彪, 王永刚. 侵袭性肺部曲霉菌病生物标志物研究进展[J]. 中华实验和临床感染病杂志(电子版), 2018, 12(06): 543-546.

Junchang Zhang, Biao Xu, Yonggang Wang. Advances on biomarkers for invasive pulmonary aspergillosis[J]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2018, 12(06): 543-546.

侵袭性肺部曲霉菌病(IPA)主要影响免疫抑制宿主,该类宿主包括血液病患者和干细胞移植受者。过去十年中,易感人群数量急剧增加,在非粒细胞减少患者中IPA发病率为0.33%~5.8%。诊断为IPA的非粒细胞减少患者预后差,主要是因诊断延迟,病死率超过80%。IPA诊断仍面临困难,尤其在非粒细胞减少的患者中,主要原因是缺少特异临床表现、微生物和影像学方法等检测敏感性较低,于定植菌中鉴别感染十分困难;故获得新的特异性生物标志物十分必要。

Invasive pulmonary aspergillosis (IPA) is an infection that mainly affects immunosuppressive hosts, including hematological patients and stem cell transplant recipients. In the past decade, the number of susceptible people has increased dramatically, and the incidence of IPA diagnosed in non-granulocytopenia patients was 0.33%-5.8%. The prognosis of non-granulocytopenia patients diagnosed as IPA is poor, mainly due to the delayed diagnosis, and the fatality rate is over 80%. IPA is still difficult to diagnose, especially in patients with non-granulocytopenia, the main reason was the lack of specific clinical manifestations, the sensitivity of microorganism and imaging method was low, and it is very difficult to identify infection in colonized bacteria. Therefore, it is necessary to obtain a new specific biomarkers.

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